ArticleInfection and immunity1994
Size heterogeneity among antigenically related Giardia lamblia variant-specific surface proteins is due to differences in tandem repeat copy number.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Comparative proteomics of threeParasitology · 2020Article
- Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins.Nature communications · 2019Article
- The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution.BMC genomics · 2010Article
- Characterization of SNAREs determines the absence of a typical Golgi apparatus in the ancient eukaryote Giardia lamblia.The Journal of biological chemistry · 2008Article
- Arginine deiminase has multiple regulatory roles in the biology of Giardia lamblia.Journal of cell science · 2008Article
- A new family of giardial cysteine-rich non-VSP protein genes and a novel cyst protein.PloS one · 2006Article
- Simultaneous expression of different variant-specific surface proteins in single Giardia lamblia trophozoites during encystation.Infection and immunity · 2002Article
- Biology of Giardia lamblia.Clinical microbiology reviews · 2001Review
- A new gene family (ariel) encodes asparagine-rich Entamoeba histolytica antigens, which resemble the amebic vaccine candidate serine-rich E. histolytica protein.Infection and immunity · 1998Article
- Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections.Microbiology and molecular biology reviews : MMBR · 1997Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giardia lamblia undergoes antigenic variation by modulating the expression of the different genes that comprise the trophozoite's variant-specific surface protein (VSP) repertoire. We studied an epitope that is conserved among VSPs expressed by cloned trophozoite lines derived from the independent G. lamblia isolates WB, G3M, Be-2, and CAT. The epitope recognized by monoclonal antibody 6E7 lies entirely within the region of tandemly repeated 65-amino-acid units that is characteristic of these size-variant VSPs. Northern (RNA) hybridization, cDNA cloning, and DNA sequence analysis indicate that size heterogeneity among these VSPs is due to differences in the number of repetitive units.
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