ArticleProceedings of the National Academy of Sciences of the United States of America1994
Single-channel currents trigger action potentials in small cultured hippocampal neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 64 citations in OpenAlex.
- Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays.Frontiers in neuroscience · 2022Article
- Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise.Frontiers in computational neuroscience · 2014Article
- Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem.The Journal of physiology · 2012Article
- Persistent membranous cross correlations due to the multiplicity of gates in ion channels.Journal of computational neuroscience · 2011Article
- Detailed numerical investigation of the dissipative stochastic mechanics based neuron model.Journal of computational neuroscience · 2008Article
- Stochastic differential equation model for cerebellar granule cell excitability.PLoS computational biology · 2008Article
- Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals.The Journal of physiology · 2002Article
- How could a chirp be more effective than a louder clock--resonant transfer of energy between subthreshold excitation pulses and excitable tissues.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous neuronal impulse activity appears to play a key role in some neural processes, such as the normal establishment of interneuronal connections during development. In addition, spontaneous impulses may be essential for the functional operation of neuronal networks. Mechanisms of spontaneous non-pacemaker impulse generation are, however, not well known. In this work, spontaneous electrical activity in small cultured hippocampal neurons from rat was studied with tight-seal recording techniques. The results demonstrate that spontaneous individual openings of single ion channels can trigger impulse generation in these high-resistance cells. First, impulses recorded in the whole-cell mode were apparently induced by spontaneous plateau-potential events showing the characteristics expected from individual openings and closures of ion channels. Second, patch-clamp recordings in the cell-attached configuration showed that openings of single ion channels in the patch membrane could trigger cellular impulses, detected as biphasic current deflections. These findings suggest that the random gating of ion channel molecules can be used as a mechanism for stochastic triggering of spontaneous impulses in mammalian central neurons.
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