ArticleNucleic acids research1994
Premature strand transfer by the HIV-1 reverse transcriptase during strong-stop DNA synthesis.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Effect of TAR hairpin stabilization on HIV-1 reverse transcription.Journal of virology · 2026Article
- HIV-1 single-transcription start-site mutants display complementary replication functions that are restored by reversion.Journal of virology · 2025Article
- HIV-1 RNAs whose transcription initiates from the third deoxyguanosine of GGG tract in the 5' long terminal repeat serve as a dominant genome for efficient provirus DNA formation.Journal of virology · 2024Article
- Retroviral nucleocapsid proteins and DNA strand transfers.Biochimie open · 2018Review
- HIV-1 tolerates changes in A-count in a small segment of the pol gene.Retrovirology · 2017Article
- Structural Insights into the HIV-1 Minus-strand Strong-stop DNA.The Journal of biological chemistry · 2016Article
- Impairment of HIV-1 cDNA synthesis by DBR1 knockdown.Journal of virology · 2014Article
- Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription.Virus research · 2013Article
- RNA structures facilitate recombination-mediated gene swapping in HIV-1.Journal of virology · 2010Article
- Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1.Nucleic acids research · 2006Article
- Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape.Journal of virology · 2005Article
- Human immunodeficiency virus type 1 subtypes have a distinct long terminal repeat that determines the replication rate in a host-cell-specific manner.Journal of virology · 2004Article
- Mismatch extension during strong stop strand transfer and minimal homology requirements for replicative template switching during Moloney murine leukemia virus replication.Journal of molecular biology · 2003Article
- Effects of limiting homology at the site of intermolecular recombinogenic template switching during Moloney murine leukemia virus replication.Journal of virology · 2001Article
- The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination.Nucleic acids research · 2001Article
- Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.RNA (New York, N.Y.) · 2001Article
- Evidence for retroviral intramolecular recombinations.Journal of virology · 2001Article
- Inhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcription.Journal of virology · 2001Article
- Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat.Journal of virology · 2001Article
- Effects of homology length in the repeat region on minus-strand DNA transfer and retroviral replication.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reverse transcription of retroviral genomes starts near the 5' end of the viral RNA by use of an associated tRNA primer. According to the current model of reverse transcription, the initial cDNA product, termed minus-strand strong-stop DNA, 'jumps' to a repeated sequence (R region) at the 3' end of the RNA template. The human retroviruses have relatively long R regions (97-247 nucleotides) when compared to murine and avian viruses (16-68 nucleotides). This suggests that the full complement of the R region is not required for strand transfer and that partial cDNA copies of the 5' R can prematurely jump to the 3' R. To test this hypothesis, we generated mutants of the human immunodeficiency virus with R region changes and analyzed whether 5' or 3' R sequences were inherited by the progeny. We found that in most cases, 5' R-encoded sequences are dominant, which is consistent with the model of reverse transcription. Using a selection protocol, however, we were also able to identify progeny viruses with R sequences derived from the original 3' R element. These results suggest that partial strong stop cDNAs can be transferred with R region homologies much shorter than 97 nucleotides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.