ArticleThe Journal of cell biology1994
Nuclear export of different classes of RNA is mediated by specific factors.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.
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Who cites it
159 citing papers in PubMed.
- The RNA helicase DDX39 contributes to the nuclear export of spliceosomal U snRNA by loading of PHAX onto RNA.Nucleic acids research · 2024Article
- The SARS-CoV-2 ORF6 protein inhibits nuclear export of mRNA and spliceosomal U snRNA.PloS one · 2024Article
- The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts.Nucleic acids research · 2023Article
- Review
- Distinct Functions of the Cap-Binding Complex in Stimulation of Nuclear mRNA Export.Molecular and cellular biology · 2019Article
- A recap of RNA recapping.Wiley interdisciplinary reviews. RNA · 2019Review
- Lariat intronic RNAs in the cytoplasm of vertebrate cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Xpo7 is a broad-spectrum exportin and a nuclear import receptor.The Journal of cell biology · 2018Article
- Article
- RNA Degradation in Neurodegenerative Disease.Advances in neurobiology · 2018Review
- Mutually Exclusive CBC-Containing Complexes Contribute to RNA Fate.Cell reports · 2017Article
- Article
- Exportin-5 mediates nuclear export of SRP RNA in vertebrates.Genes to cells : devoted to molecular & cellular mechanisms · 2015Article
- HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment.Nucleic acids research · 2014Article
- p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly.Nucleic acids research · 2014Article
- mRNA quality control pathways in Saccharomyces cerevisiae.Journal of biosciences · 2013Review
- Routing of Biomolecules and Transgenes' Vectors in Nuclei of Oocytes.Journal of fertilization in vitro · 2012Article
- Pol II-directed short RNAs suppress the nuclear export of mRNA.Plant molecular biology · 2010Article
- Cajal body surveillance of U snRNA export complex assembly.The Journal of cell biology · 2010Article
- A genomic glance at the components of the mRNA export machinery in Plasmodium falciparum.Communicative & integrative biology · 2010Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various classes of RNA are exported from the nucleus to the cytoplasm, including transcripts of RNA polymerase I (large ribosomal RNAs), II (U-rich small nuclear RNAs [U snRNAs], mRNAs), and III (tRNAs, 5S RNA). Here, evidence is presented that some steps in the export of various classes of nuclear RNA are mediated by specific rather than common factors. Using microinjection into Xenopus oocytes, it is shown that a tRNA, a U snRNA, and an mRNA competitively inhibit their own export at concentrations at which they have no effect on the export of heterologous RNAs. While the export of both U snRNAs and mRNAs is enhanced by their 7-methyl guanosine cap structures, factors recognizing this structure are found to be limiting in concentration only in the case of U snRNAs. In addition to the specific factors, evidence for steps in the export process that may be common to at least some classes of RNA are provided by experiments in which synthetic homopolymeric RNAs are used as inhibitors.
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Registered trials
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