ArticleCell and tissue research1994
Nitric oxide synthase immunoreactivity in the enteric nervous system of the developing human digestive tract.
Article in Cell and tissue research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 121 citations in OpenAlex.
- Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development.eLife · 2024Article
- Nitrergic and Substance P Immunoreactive Neurons in the Enteric Nervous System of the Bottlenose Dolphin (Animals : an open access journal from MDPI · 2021Article
- Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon.Cell and tissue research · 2021Article
- Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine.Stem cell reports · 2017Article
- Chagasic megacolon: enteric neurons and related structures.Histochemistry and cell biology · 2014Review
- What neurons hide behind calretinin immunoreactivity in the human gut?Histochemistry and cell biology · 2014Article
- Diabetes-related alterations in the enteric nervous system and its microenvironment.World journal of diabetes · 2012Article
- Neurochemical coding of enteric neurons in adult and embryonic zebrafish (Danio rerio).The Journal of comparative neurology · 2010Article
- Development of enteric neuron diversity.Journal of cellular and molecular medicine · 2009Review
- The human neonatal small intestine has the potential for arginine synthesis; developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes.BMC developmental biology · 2008Article
- The developmental stage and cell type dependent phosphorylation of eNOS in murine enteric mucosa and myenteric plexus.Journal of molecular histology · 2007Article
- Alteration of nitrergic neuromuscular transmission as a result of acute experimental colitis in rat.Journal of veterinary science · 2006Article
- Myenteric nitrergic neurons along the rat esophagus: evidence for regional and strain differences in age-related changes.Histochemistry and cell biology · 2003Article
- Article
- Quantitative distribution of NADPH-diaphorase-positive myenteric neurons in different segments of the developing chicken small intestine and colon.The Histochemical journal · 2000Article
- Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations.British journal of pharmacology · 2000Article
- A comparative study of esophageal and anorectal motility in myotonic dystrophy.Digestive diseases and sciences · 1999Article
- Article
- Distribution of NADPH diaphorase-positive neurons in the enteric nervous system of the rabbit intestine.Neurochemical research · 1998Article
- Nitric oxide as a modulator of intestinal water and electrolyte transport.Digestive diseases and sciences · 1998Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated indirectly the presence of nitric oxide in the enteric nervous system of the digestive tract of human fetuses and newborns by nitric oxide synthase (NOS) immunocytochemistry and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) histochemistry. In the stomach, NOS immunoactivity was confined to the myenteric plexus and nerve fibres in the outer smooth musculature; few immunoreactive nerve cell bodies were found in ganglia of the outer submucous plexus. In the pyloric region, a few nitrergic perikarya were seen in the inner submucous plexus and some immunoreactive fibers were found in the muscularis mucosae. In the small intestine, nitrergic neurons clustered just underneath or above the topographical plane formed by the primary nerve strands of the myenteric plexus up to the 26th week of gestation, after which stage, they occurred throughout the ganglia. Many of their processes contributed to the dense fine-meshed tertiary nerve network of the myenteric plexus and the circular smooth muscle layer. NOS-immunoreactive fibres directed to the circular smooth muscle layer originated from a few NOS-containing perikarya located in the outer submucous plexus. In the colon, caecum and rectum, labelled nerve cells and fibres were numerous in the myenteric plexus; they were also found in the outer submucous plexus. The circular muscle layer had a much denser NOS-immunoreactive innervation than the longitudinally oriented taenia. The marked morphological differences observed between nitrergic neurons within the developing human gastrointestinal tract, together with the typical innervation pattern in the ganglionic and aganglionic nerve networks, support the existence of distinct subpopulations of NOS-containing enterice neurons acting as interneurons or (inhibitory) motor neurons.
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