ArticleJournal of virology1994
Antigenic determinants of measles virus hemagglutinin associated with neurovirulence.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins.Cell host & microbe · 2026Article
- Developing monoclonal antibody therapies for measles could lead to adverse pathogen evolution.PLoS biology · 2026Article
- Identification of a new polymorphism on the wild-type canine distemper virus genome: could this contribute to vaccine failures?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Phylogenetic analysis of the wild-type strains of canine distemper virus circulating in the United States.Virology journal · 2018Article
- Review
- Review
- Molecular evolution of haemagglutinin (H) gene in measles virus.Scientific reports · 2015Article
- The receptor attachment function of measles virus hemagglutinin can be replaced with an autonomous protein that binds Her2/neu while maintaining its fusion-helper function.Journal of virology · 2013Article
- Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.Journal of virology · 2013Article
- Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies.PloS one · 2012Article
- Isolation and complete nucleotide sequence of the measles virus IMB-1 strain in China.Virologica Sinica · 2010Article
- Structure of the measles virus hemagglutinin bound to the CD46 receptor.Nature structural & molecular biology · 2010Article
- Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins improves titer and selectivity.Gene therapy · 2009Article
- Disease duration determines canine distemper virus neurovirulence.Journal of virology · 2007Article
- hsp72, a host determinant of measles virus neurovirulence.Journal of virology · 2006Article
- Wild-type measles virus in brain tissue of children with subacute sclerosing panencephalitis, Argentina.Emerging infectious diseases · 2003Article
- Identification of immunodominant neutralizing epitopes on the hemagglutinin protein of rinderpest virus.Journal of virology · 2002Article
- Recombinant measles viruses expressing altered hemagglutinin (H) genes: functional separation of mutations determining H antibody escape from neurovirulence.Journal of virology · 2001Article
- CD150 (SLAM) is a receptor for measles virus but is not involved in viral contact-mediated proliferation inhibition.Journal of virology · 2001Article
- Measles virus spread between neurons requires cell contact but not CD46 expression, syncytium formation, or extracellular virus production.Journal of virology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The biological activity of monoclonal antibodies specific for the hemagglutinin protein of measles virus strain CAM recognizing six epitope groups according to their binding properties to measles virus strain CAM/R401 was investigated in vivo in our rat model of measles encephalitis. When injected intraperitoneally into measles virus-infected suckling rats, some monoclonal antibodies modified the disease process and prevented the necrotizing encephalopathy seen in untreated animals. The analysis of measles virus brain isolates revealed emergence of variants that resisted neutralization with the passively transferred selecting monoclonal antibody but not with other monoclonal antibodies. Monoclonal antibody escape mutants were also isolated in vitro, and their neurovirulence varied in the animal model. Sequence data from the hemagglutinin gene of measles virus localize a major antigenic surface determinant of the hemagglutinin protein between amino acid residues 368 and 396, which may be functionally important for neurovirulence. The data indicate that the interaction of antibodies with the measles virus H protein plays an important role in the selection of neurovirulent variants. These variants have biological properties different from those of the parent CAM virus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.