ArticlePflugers Archiv : European journal of physiology1993
Properties of spontaneous inward currents in rabbit pulmonary artery smooth muscle cells.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Vascular mechanotransduction.Physiological reviews · 2023Review
- NaFrontiers in physiology · 2020Article
- Calcium signals that determine vascular resistance.Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Pulmonary circulation · 2015Review
- Calcium signaling in smooth muscle.Cold Spring Harbor perspectives in biology · 2011Review
- Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling.Comprehensive Physiology · 2011Review
- TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells.The Journal of physiology · 2010Article
- Membrane current oscillations in descending vasa recta pericytes.American journal of physiology. Renal physiology · 2008Article
- Ca2+ signalling in urethral interstitial cells of Cajal.The Journal of physiology · 2006Review
- Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells.The Journal of physiology · 2002Article
- Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra.The Journal of physiology · 1999Article
- Elementary and global aspects of calcium signalling.The Journal of physiology · 1997Review
- Analysis of the time course of calcium-activated chloride "tail" currents in rabbit portal vein smooth muscle cells.Pflugers Archiv : European journal of physiology · 1996Article
- Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra.British journal of pharmacology · 1996Article
- Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein.British journal of pharmacology · 1996Article
- Effect of temperature on spontaneous Ca2+-activated Cl- currents in rabbit portal vein cells.Pflugers Archiv : European journal of physiology · 1995Article
- Effect of frusemide, ethacrynic acid and indanyloxyacetic acid on spontaneous Ca-activated currents in rabbit portal vein smooth muscle cells.British journal of pharmacology · 1995Article
- cAMP accelerates the decay of stretch-activated inward currents in guinea-pig urinary bladder myocytes.The Journal of physiology · 1995Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Spontaneous inward and outward currents were studied with perforated patch recording in freshly dispersed rabbit pulmonary artery smooth muscle cells. With physiological potassium concentrations, spontaneous outward and inward currents were recorded at negative membrane potentials. Ion substitution experiments revealed that the outward and inward currents were respectively potassium and chloride conductance increases. Both conductances were abolished by bath application of caffeine (2-10 mM), which releases calcium from internal stores. The rise time and half-decay time of spontaneous potassium currents were both about 25 ms. The spontaneous chloride current has a rise time of 30 ms and decayed exponentially with a time constant (tau) of 70 ms at -50 mV. The tau value was increased by depolarization and increased e-fold for a change of 99 mV in membrane potential. In every cell examined when the spontaneous currents occurred as biphasic events, typically between -20 mV and -40 mV, outward currents preceded inward currents in over 90% of these events whereas the inward current always preceded the outward current in caffeine- and noradrenaline-evoked responses. An explanation for these data is that there may be localization of some chloride channels with respect to the caffeine-sensitive calcium store.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.