ArticleProceedings of the National Academy of Sciences of the United States of America1994
Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 82 citations in OpenAlex.
- Regulation of nucleotide excision repair by wild-type HRAS signaling in head and neck cancer.Cancer gene therapy · 2025Article
- A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms.International journal of molecular sciences · 2023Review
- Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation.The American journal of pathology · 2013Article
- Surface-affinity profiling to identify host-pathogen interactions.Infection and immunity · 2011Article
- Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells.Journal of cancer research and clinical oncology · 2011Article
- Circulating cell death products predict clinical outcome of colorectal cancer patients.BMC cancer · 2009Article
- Article
- Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene.The American journal of pathology · 2006Article
- Ets target genes: past, present and future.Oncogene · 2000Review
- Regulation of keratin and integrin gene expression in cancer and drug resistance.Cytotechnology · 1998Article
- Development of an epithelium-specific expression cassette with human DNA regulatory elements for transgene expression in lung airways.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Methylation of an ETS site in the intron enhancer of the keratin 18 gene participates in tissue-specific repression.Molecular and cellular biology · 1997Article
- Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1.Molecular and cellular biology · 1997Article
- E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts.Molecular and cellular biology · 1997Article
- Pattern of expression of intermediate cytokeratin filaments in the thyroid gland: an immunohistochemical study of simple and stratified epithelial-type cytokeratins.Virchows Archiv : an international journal of pathology · 1997Article
- Oncogenic regulation and function of keratins 8 and 18.Cancer metastasis reviews · 1996Review
- ras oncogene-dependent activation of the P4 promoter of minute virus of mice through a proximal P4 element interacting with the Ets family of transcription factors.Journal of virology · 1996Article
- Cytokeratin 18 expression in squamous cell carcinoma of the head and neck.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1996Article
- Specific activation in jun-transformed avian fibroblasts of a gene (bkj) related to the avian beta-keratin gene family.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor.Molecular and cellular biology · 1995Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Keratin 8 (K8) and keratin 18 (K18) are intermediate filament proteins normally expressed in simple epithelial tissues and persistently expressed in a wide variety of carcinomas. Ectopic expression of K8 and K18 occurs in some epidermal and murine skin carcinomas induced by chemical carcinogenesis or oncogenic ras expression. We show here that K18 is a direct target of the Ras signal transduction pathway, by demonstrating that activated Ha-Ras, as well as activated Src, Lck, or Raf, stimulates the transcription of K18. This activation is mediated by an enhancer element containing essential and closely spaced Ets and AP-1 transcription factor binding sites. Oncogene activation of K18 transcription provides a molecular explanation for the persistent and sometimes unexpected expression of K18 in such a wide variety of tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.