ArticleInfection and immunity1994
Modulation of cell surface-associated mannoprotein antigen expression in experimental candidal vaginitis.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- A representative of arylcyanomethylenequinone oximes effectively inhibits growth and formation of hyphae inSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Studies of Immune Responses in Candida vaginitis.Pathogens (Basel, Switzerland) · 2015Review
- Anticandidal immunity and vaginitis: novel opportunities for immune intervention.Infection and immunity · 2007Review
- A novel glyco-conjugate vaccine against fungal pathogens.The Journal of experimental medicine · 2005Article
- Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: a novel dimorphism-dependent mechanism to escape the host's immune response.Infection and immunity · 2004Article
- Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine.Infection and immunity · 2002Article
- Generation of a recombinant 65-kilodalton mannoprotein, a major antigen target of cell-mediated immune response to Candida albicans.Infection and immunity · 2000Article
- Defective induction of interleukin-12 in human monocytes by germ-tube forms of Candida albicans.Infection and immunity · 2000Article
- Biochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicans.Infection and immunity · 2000Article
- Low levels of antigenic variability in fluconazole-susceptible and -resistant Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis.Clinical and diagnostic laboratory immunology · 1999Article
- Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans.Clinical microbiology reviews · 1999Review
- MP1 encodes an abundant and highly antigenic cell wall mannoprotein in the pathogenic fungus Penicillium marneffei.Infection and immunity · 1998Article
- Serologic response to cell wall mannoproteins and proteins of Candida albicans.Clinical microbiology reviews · 1998Review
- Protective role of antimannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats.Infection and immunity · 1997Article
- Immunopathogenesis of recurrent vulvovaginal candidiasis.Clinical microbiology reviews · 1996Review
- Rats clearing a vaginal infection by Candida albicans acquire specific, antibody-mediated resistance to vaginal reinfection.Infection and immunity · 1995Article
- Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis.Infection and immunity · 1995Article
- Noninhibitory binding of human interleukin-2-activated natural killer cells to the germ tube forms of Candida albicans.Infection and immunity · 1995Article
- Virulence attributes of low-virulence organisms.Infectious diseases in obstetrics and gynecology · 1994Article
- Expression of the complement-binding protein (MP60) of Candida albicans in experimental vaginitis.MycopathologiaArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The monoclonal antibody (MAb) AF1 recognizes an oligosaccharide epitope present on highly immunogenic and immunomodulatory mannoproteins (MP) of Candida albicans. The expression of this epitope (AF1-MP) during experimental candidal vaginitis was studied in two strains of C. albicans (3153 and CA-2) which were equally vaginopathic but differed in the mode of hypha formation in the vagina. In both strains, immunofluorescence of vaginal samples, taken 1 h after challenge, revealed an intense, MAb AF1-specific labelling of the yeast cells. This labelling was very scarce in fungal cells taken at 24 h and on subsequent days during the development of filamentous forms. Electron-microscopic gold immunolabelling observations showed that molecules carrying AF1-MP spanned the entire cell wall in the initial yeast cells but were absent on the cell surface and in the outermost, capsular layer of the cell wall of the germ tubes and filamentous forms. In both strains, at any time and for any form of intravaginal growth, AF1-MP was clearly expressed in the cytoplasm and cytoplasmic vesicles, and was fully incorporated into the inner layers of the cell wall. As seen by immunofluorescence, the vaginal fluid from C. albicans-infected rats did not hinder the expression of AF1-MP on the yeast cells surface in vitro. In electron-microscopic gold immunolabelling, a hypha-specific MAb (3D9) labelled the surface of the hyphal but not of the yeast cells of C. albicans harvested from rat vagina. Overall, these data strongly suggest that cell surface expression of MP antigen is modulated during intravaginal growth and morphogenesis of C. albicans.
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