ArticleThe American journal of pathology1994
Effects of interleukin-3 with or without the c-kit ligand, stem cell factor, on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00050193 (Determining the Pathogenesis of Systemic Pediatric-Onset Mastocytosis), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determining the Pathogenesis of Systemic Pediatric-Onset Mastocytosis
Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- Rapid desensitization of humanized mice with anti-human FcεRIα monoclonal antibodies.The Journal of allergy and clinical immunology · 2020Article
- Short-term in vitro culture of purity and highly functional rat bone marrow-derived mast cells.In vitro cellular & developmental biology. Animal · 2018Article
- Mast Cells Are Activated byFrontiers in immunology · 2018Article
- Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils.Biochemistry and biophysics reports · 2017Article
- Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?Clinical and translational medicine · 2016Article
- Roles and relevance of mast cells in infection and vaccination.Journal of biomedical research · 2016Review
- IL-3 contributes to development of lupus nephritis in MRL/lpr mice.Kidney international · 2015Article
- Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor.Stem cell reports · 2014Article
- Article
- Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.The Journal of biological chemistry · 2012Article
- The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II.BMC immunology · 2010Article
- Distinguishing mast cell and granulocyte differentiation at the single-cell level.Cell stem cell · 2010Article
- IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro.Laboratory investigation; a journal of technical methods and pathology · 2008Article
- Loss of histochemical identity in mast cells lacking carboxypeptidase A.Molecular and cellular biology · 2005Article
- Basophils initiate IL-4 production during a memory T-dependent response.The Journal of experimental medicine · 2004Article
- Paediatric mastocytosis.Archives of disease in childhood · 2002Article
- Cytokines regulate development of human mast cells from hematopoietic progenitors.International journal of hematology · 2002Review
- IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Age-related changes in dermal mast cell prevalence in BALB/c mice: functional importance and correlation with dermal mast cell expression of Kit.Immunology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We assessed the ultrastructure and the cell-surface expression of receptors for immunoglobulin E (Fc epsilon R), and c-kit, the receptor for stem cell factor (SCF), in mouse basophils and mast cells present in short-term cultures of mouse bone marrow cells in interleukin-3 (IL-3) with or without SCF. Basophils did not develop increased numbers of cytoplasmic granules and underwent apoptosis in cultures containing IL-3 and SCF, whereas mast cells thrived and developed increased numbers of granules. Basophils were nearly all Fc epsilon R+ c-kit- when sorted after culture in IL-3 and SCF; most mast cells were Fc epsilon R+ c-kit+. However, a second population of Fc epsilon R+ c-kit- mast cells was present after culture in IL-3 and SCF. These c-kit receptor-negative mast cells were less mature than c-kit+ mast cells and contained significantly fewer cytoplasmic granules than the c-kit+ mast cells present in the same cultures (P < 0.001). Thus, mouse basophils express little or no c-kit receptor on their surface, nor can they survive for long periods in SCF-supplemented cultures. By contrast, mouse mast cells seem to express the Fc epsilon R early in their development, even before they express detectable c-kit receptors on their surface. IL-3 promotes cytoplasmic granule formation in immature mast cells, but even more granules are formed when c-kit receptor-positive immature mast cells are cultured in both SCF and IL-3.
Indexed as
Identifiers
7507298PMC1887107W1593632872What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.