ArticleAnatomy and embryology1993
The rat renal nerves during development.
Article in Anatomy and embryology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 92 citations in OpenAlex.
- Oxidative Stress in Maternal and Offspring Kidney Disease and Hypertension: A Life-Course Perspective.Antioxidants (Basel, Switzerland) · 2025Review
- Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics - 2024 update.The Journal of physiology · 2025Review
- Kidney Programming and Hypertension: Linking Prenatal Development to Adulthood.International journal of molecular sciences · 2024Review
- Preterm Birth and Kidney Health: From the Womb to the Rest of Life.Children (Basel, Switzerland) · 2024Review
- Neuroimmune interplay in kidney health and disease: Role of renal nerves.Autonomic neuroscience : basic & clinical · 2023Review
- Innervation of the developing kidney in vivo and in vitro.Biology open · 2023Article
- 2019 Consensus Statement of the Taiwan Hypertension Society and the Taiwan Society of Cardiology on Renal Denervation for the Management of Arterial Hypertension.Acta Cardiologica Sinica · 2019Review
- Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life?International journal of molecular sciences · 2017Review
- Article
- Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics.The Journal of physiology · 2016Review
- Role of renal sensory nerves in physiological and pathophysiological conditions.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Methodological standardization for the pre-clinical evaluation of renal sympathetic denervation.JACC. Cardiovascular interventions · 2014Review
- Renal sympathetic nervous system and the effects of denervation on renal arteries.World journal of cardiology · 2014Review
- The role of nonpharmacologic device interventions in the management of drug-resistant hypertension.Current atherosclerosis reports · 2014Review
- Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension.International journal of hypertension · 2011Article
- Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure.Canadian journal of physiology and pharmacology · 2010Article
- Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats.International journal of colorectal disease · 2010Article
- Methods for imaging Renin-synthesizing, -storing, and -secreting cells.International journal of hypertension · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The prenatal and postnatal development of the innervation of the rat kidney has been investigated using immunocytochemical methods. The efferent innervation was studied using dopamine-beta-hydroxylase and neuropeptide Y antibodies. Calcitonin gene related peptide and substance P antibodies were used to investigate the afferent innervation. Kidneys from embryos of 14 to 20 days, from newborn rats, and from animals of 4, 10, 12, 21, 38, 60, and 90 days of age were studied. Slices of whole kidneys were analyzed, and frozen sections were used to investigate the location of the nerves in more detail. Both afferent and efferent nerves are observed inside the kidney by embryonic day 16. At birth, the afferent nerves are found (1) forming a rich plexus in the renal pelvis; (2) associated with the renal vasculature as far as the interlobular arteries (cortical radial arteries) and (3) in the corticomedullary connective tissue. The efferent innervation appears, at birth, to extend to the interlobular arteries and to the afferent arterioles of the perihilar juxtamedullary nephrons. The efferent innervation increases rapidly during the following days, and by postnatal day 21 a distribution of the innervation similar to that of the adult is observed. While the afferent innervation reaches the major target regions of the kidney by birth, the efferent does most of its expansion into the kidney postnatally. Afferent and efferent fibers are found, extrarenally and intrarenally, in the same nerve bundles. This proximity between afferent and efferent fibers may represent anatomical bases for their interaction in the adult as well as during development.
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