ArticleProceedings of the National Academy of Sciences of the United States of America1994
A minority of carcinoma cells producing acidic fibroblast growth factor induces a community effect for tumor progression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- scCross: a deep generative model for unifying single-cell multi-omics with seamless integration, cross-modal generation, and in silico exploration.Genome biology · 2024Article
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- The Unfolded Protein Response at the Tumor-Immune Interface.Frontiers in immunology · 2022Review
- Cancer cell states and emergent properties of the dynamic tumor system.Genome research · 2021Article
- Article
- Article
- Evolution of cooperation in an epithelium.Journal of the Royal Society, Interface · 2019Article
- Cooperation among cancer cells: applying game theory to cancer.Nature reviews. Cancer · 2019Review
- Insidious communication amongst cancer cells.Molecular & cellular oncology · 2018Article
- Evolutionary emergence of angiogenesis in avascular tumors using a spatial public goods game.PloS one · 2017Article
- The evolving paradigm of cell-nonautonomous UPR-based regulation of immunity by cancer cells.Oncogene · 2016Review
- Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.The Journal of investigative dermatology · 2014Article
- Dynamics of growth factor production in monolayers of cancer cells and evolution of resistance to anticancer therapies.Evolutionary applications · 2013Article
- Evolutionary game theory of growth factor production: implications for tumour heterogeneity and resistance to therapies.British journal of cancer · 2013Article
- The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy.International journal of clinical and experimental medicine · 2013Article
- Recombinant adenovirus encoding vasohibin prevents tumor angiogenesis and inhibits tumor growth.Cancer science · 2010Article
- Cancer as an evolutionary and ecological process.Nature reviews. Cancer · 2006Review
- Article
- Nuclear 24 kD fibroblast growth factor (FGF)-2 confers metastatic properties on rat bladder carcinoma cells.Oncogene · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It is generally accepted that primary tumors become heterogeneous as a consequence of tumor-cell genetic instability. Clonal dominance has been shown to occur in some experimental models allowing a subpopulation of cells to overgrow the primary heterogeneous tumor and to metastasize. Alternatively, interactions among coexisting tumor subpopulations may contribute to the emergence of a malignant invasive primary solid tumor. We asked the question whether emergence of carcinoma cells producing a growth/dissociating factor within a tumor cell population may be a determinant for tumor progression and for clonal dominance. To mimic such a situation, we have investigated the impact of tumor subpopulation heterogeneity in an in vivo model in which mixtures of carcinoma cells that differ in their ability to produce acidic fibroblast growth factor are injected into nude mice. Our data indicate that a growth-factor-producing cell subpopulation can confer increased tumorigenicity to an entire cell population and subsequently elicit a shorter delay for appearance of metastasis. A community effect via cell interactions may account for a heterogeneous tumor cell population rather than clonal dominance during progression of certain tumor types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.