ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
Alpha 1-adrenoceptor subtype affinities of drugs for the treatment of prostatic hypertrophy. Evidence for heterogeneity of chloroethylclonidine-resistant rat renal alpha 1-adrenoceptor.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 79 citations in OpenAlex.
- The effect of first dose of tamsulosin on flow rate and its predictive ability on the improvement of LUTS in men with BPH in the mid-term.International urology and nephrology · 2013Trial
- Tamsulosin shows a higher unbound drug fraction in human prostate than in plasma: a basis for uroselectivity?British journal of clinical pharmacology · 2011Trial
- The selectivity of α-adrenoceptor agonists for the human α1A, α1B, and α1D-adrenoceptors.Pharmacology research & perspectives · 2021Article
- α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics.British journal of clinical pharmacology · 2011Review
- Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
- Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms.Drugs & aging · 2002Review
- Review
- Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Benign prostatic hyperplasia. Practical treatment guidelines.Drugs & aging · 1997Review
- Comparison of adrenoceptor subtype expression in porcine and human bladder and prostate.Urological research · 1997Article
- The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor.British journal of pharmacology · 1996Article
- Comparison of guinea-pig, bovine and rat alpha 1-adrenoceptor subtypes.British journal of pharmacology · 1996Article
- Effects of noradrenaline and neuropeptide Y on rat mesenteric microvessel contraction.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Classification of alpha 1-adrenoceptor subtypes.Naunyn-Schmiedeberg's archives of pharmacology · 1995Review
- Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline.British journal of pharmacology · 1995Article
- Functional evidence equating the pharmacologically-defined alpha 1A- and cloned alpha 1C-adrenoceptor: studies in the isolated perfused kidney of rat.British journal of pharmacology · 1995Article
- Comparison of alpha 1A- and alpha 1B-adrenoceptor coupling to inositol phosphate formation in rat kidney.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Comparison of cloned and pharmacologically defined rat tissue alpha 1-adrenoceptor subtypes.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle.British journal of pharmacology · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used radioligand binding and inositol phosphate accumulation studies to determine the affinity at mixed alpha 1A- and alpha 1B-adrenoceptors (rat cerebral cortex and kidney), alpha 1A-adrenoceptors (rat cerebral cortex and kidney following inactivation of alpha 1B-adrenoceptors by chloroethylclonidine treatment) and alpha 1B-adrenoceptors (rat spleen) for drugs currently under investigation for the treatment of benign prostatic hypertrophy, alfuzosin, naftopidil and (-)- and (+)-tamsulosin. Alfuzosin and naftopidil had similar affinities in all model systems (approximately 10 nM and 130 nM, respectively) and lacked relevant selectivity for alpha 1-adrenoceptor subtypes. Their potency to inhibit noradrenaline-stimulated inositol phosphate formation in cerebral cortex matched their affinities as determined in the binding studies. Tamsulosin had higher affinity at alpha 1A- than at alpha 1B-adrenoceptors, and was slightly more potent than alfuzosin and naftopidil at alpha 1B- and considerably more potent at alpha 1A-adrenoceptors. However, the interaction of the tamsulosin isomers with chloroethylclonidine-insensitive (alpha 1A-like) adrenoceptors was complex. A detailed analysis of the tamsulosin data and those obtained with other drugs, most notably noradrenaline and oxymetazoline, suggested that chloroethylclonidine-insensitive alpha 1-adrenoceptors may be heterogeneous and that this heterogeneity may differ between cerebral cortex and kidney of the rat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.