ArticleNucleic acids research1993
Selective optimization of the Rev-binding element of HIV-1.
Article in Nucleic acids research, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 121 citations in OpenAlex.
- Structure of an RNA Aptamer that Can Inhibit HIV-1 by Blocking Rev-Cognate RNA (RRE) Binding and Rev-Rev Association.Structure (London, England : 1993) · 2018Article
- A new HIV-1 Rev structure optimizes interaction with target RNA (RRE) for nuclear export.Journal of structural biology · 2018Article
- High-affinity RNA Aptamers Against the HIV-1 Protease Inhibit Both In Vitro Protease Activity and Late Events of Viral Replication.Molecular therapy. Nucleic acids · 2015Article
- Rationally manipulating aptamer binding affinities in a stem-loop molecular beacon.Bioconjugate chemistry · 2014Article
- Cell-specific aptamers as emerging therapeutics.Journal of nucleic acids · 2011Article
- A class I ligase ribozyme with reduced Mg2+ dependence: Selection, sequence analysis, and identification of functional tertiary interactions.RNA (New York, N.Y.) · 2009Article
- Article
- An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro.RNA (New York, N.Y.) · 2008Article
- Arginine-rich motifs present multiple interfaces for specific binding by RNA.RNA (New York, N.Y.) · 2005Article
- Evolvability of the mode of peptide binding by an RNA.RNA (New York, N.Y.) · 2005Article
- Colorimetric biosensors based on DNAzyme-assembled gold nanoparticles.Journal of fluorescence · 2004Review
- Combinatorial minimization and secondary structure determination of a nucleotide synthase ribozyme.RNA (New York, N.Y.) · 2003Article
- Selections for constituting new RNA-protein interactions in catalytic RNP.Nucleic acids research · 2003Article
- Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer.Nucleic acids research · 2002Article
- Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase.Journal of virology · 2002Article
- The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The scene of a frozen accident.RNA (New York, N.Y.) · 2000Article
- Anti-Rex aptamers as mimics of the Rex-binding element.Journal of virology · 1999Article
- Polyvalent Rev decoys act as artificial Rev-responsive elements.Journal of virology · 1999Article
- NMR evidence for a base triple in the HIV-2 TAR C-G.C+ mutant-argininamide complex.Nucleic acids research · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA molecules that can bind to the Rev protein of HIV-1 have been isolated from random sequence nucleic acid pools based on a minimal Rev-binding element (RBE) found within the Rev Responsive Element (RRE). While the selected sequences are related to the wild-type element, they also contain substitutions that allow them to bind Rev up to 10-fold better in vitro. A hypothesized homopurine pairing at G48:G71 is generally replaced by A48:A71; the occasional selection of C48:A71 suggests that R71 may be in a syn conformation. These data support the structural model for the RBE originally proposed by Bartel et al. (1). Additional interactions with the Rev protein are promoted by the sequence CUC ... UYGAG, found in one class of high-affinity aptamers, but absent from the wild-type element. Within each class of aptamers different residues and substructures covary with one another to generate optimal Rev-binding surfaces. The interdependencies of different nucleotide substitutions suggest structural models for both the wild-type RBE and the selected high-affinity aptamers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.