ArticleThe American journal of pathology1993
Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions.
Article in The American journal of pathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 157 citations in OpenAlex.
- Long non-coding RNA lncAPAT promotes atherosclerotic plaque instability by targeting ribosomal protein L22.Clinical and translational medicine · 2026Article
- Evolutionary Patterns of Collagen Fiber Arrangement and Calcification in Atherosclerosis.Research (Washington, D.C.) · 2025Article
- Rubbing-Assisted Approach for Fabricating Oriented Nanobiomaterials.Micromachines · 2022Review
- Laboratory Grown Biofilms of Bacteria Associated with Human Atherosclerotic Carotid Arteries Release Collagenases and Gelatinases during Iron-Induced Dispersion.Microbiology spectrum · 2022Article
- Opinion: On the Way towards the New Paradigm of Atherosclerosis.International journal of molecular sciences · 2022Review
- Macrophages in Atherosclerosis, First or Second Row Players?Biomedicines · 2021Review
- Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease.Journal of clinical medicine · 2021Review
- The Management of Coronary Artery Disease in Ethiopia: Emphasis on Revascularization.Ethiopian journal of health sciences · 2021Review
- Development of a Collagen Fibre Remodelling Rupture Risk Metric for Potentially Vulnerable Carotid Artery Atherosclerotic Plaques.Frontiers in physiology · 2021Article
- Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells.Biochimica et biophysica acta. General subjects · 2020Article
- Vascular smooth muscle cells in atherosclerosis.Nature reviews. Cardiology · 2019Review
- Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke.Journal of clinical medicine · 2019Article
- Zooming in on the genesis of atherosclerotic plaque microcalcifications.The Journal of physiology · 2016Review
- Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat-fed ApoE-knockout mice.Experimental and therapeutic medicine · 2015Article
- A comparison between the principal stress direction and collagen fiber orientation in coronary atherosclerotic plaque fibrous caps.Medical & biological engineering & computing · 2015Article
- Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries.BMC genomics · 2014Article
- Atherosclerosis and interferon-γ: new insights and therapeutic targets.Trends in cardiovascular medicine · 2014Review
- Article
- 3,4-Methylenedioxymethamphetamine alters left ventricular function and activates nuclear factor-Kappa B (NF-κB) in a time and dose dependent manner.International journal of molecular sciences · 2010Article
- RFXB and its splice variant RFXBSV mediate the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells.Nucleic acids research · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Because collagen is a major component of the human atherosclerotic plaque, factors controlling collagen synthesis may have a profound influence on the volume growth of these intimal lesions. In human arteries, we compared normal vs atherosclerotic media vs intimas for type I collagen gene expression using immunocytochemistry and in situ messenger RNA hybridization with subsequent correlations with plaque topographical features. We also determined the associations of such collagen gene expression with proximity to monocyte/macrophages and T lymphocytes. Type I collagen synthesis appears to be upregulated in atherosclerotic plaques compared with their underlying medias and normal internal mammary arteries and coronary diffuse intimal thickenings. At least in established and advanced coronary and carotid plaques, type I collagen gene expression is focal and especially prevalent in fibrous cap and vascularized regions. Although macrophages and type I procollagen messenger RNA and protein are both found in atherosclerotic plaques, no apparent spatial correlation between macrophage presence and type I procollagen presence was found within these atherosclerotic intimas. Type I procollagen presence appears to be negatively associated with the spatial presence of T cells. Thus, human atherosclerotic plaques exhibit nonuniform patterns of type I collagen gene expression. Although the biochemical determinants of this focal gene expression have yet to be determined, it is conceivable that stimulatory/inhibitory cytokines and other factors (eg hemodynamics) play important roles in determining the focal nature of collagen synthesis in atherosclerosis.
Indexed as
Identifiers
7504887PMC1887272W2509477What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.