ArticlePflugers Archiv : European journal of physiology1993
K+ channels in the basolateral membrane of rat cortical collecting duct.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney KAmerican journal of physiology. Renal physiology · 2026Article
- Inwardly rectifying KAmerican journal of physiology. Cell physiology · 2022Review
- Potassium conservation is impaired in mice with reduced renal expression of Kir4.1.American journal of physiology. Renal physiology · 2018Article
- Role and mechanisms of regulation of the basolateral KActa physiologica (Oxford, England) · 2017Review
- The expression, regulation, and function of Kir4.1 (Kcnj10) in the mammalian kidney.American journal of physiology. Renal physiology · 2016Review
- Disruption of KCNJ10 (Kir4.1) stimulates the expression of ENaC in the collecting duct.American journal of physiology. Renal physiology · 2016Article
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- Basolateral membrane K+ channels in renal epithelial cells.American journal of physiology. Renal physiology · 2012Review
- Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.American journal of physiology. Renal physiology · 2008Article
- Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice.Pflugers Archiv : European journal of physiology · 2006Article
- Molecular diversity and regulation of renal potassium channels.Physiological reviews · 2005Review
- Nitric oxide links the apical Na+ transport to the basolateral K+ conductance in the rat cortical collecting duct.The Journal of general physiology · 1997Article
- K+ channels in the basolateral membrane of rat cortical collecting duct are regulated by a cGMP-dependent protein kinase.Pflugers Archiv : European journal of physiology · 1995Article
- A ubiquitous non-selective cation channel in the mouse renal tubule with variable sensitivity to calcium.Pflugers Archiv : European journal of physiology · 1994Article
- pH dependence of K+ conductances of rat cortical collecting duct principal cells.Pflugers Archiv : European journal of physiology · 1994Article
- Analysing ion channels with hidden Markov models.Pflugers Archiv : European journal of physiology · 1994Article
- Regulation of tubular transport via ion channels.The Clinical investigator · 1993Review
- Recent advances in the field of renal potassium excretion: what can we learn from potassium channels?The Yale journal of biology and medicineReview
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2 authors.
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Abstract
Impalement studies in isolated perfused cortical collecting ducts (CCD) of rats have shown that the basolateral membrane possesses a K+ conductive pathway. In the present study this pathway was investigated at the single-channel level using the patch-clamp technique. Patch-clamp recordings were obtained from enzymatically isolated CCD segments and freshly isolated CCD cells with the conventional cell-free, cell-attached and the cell-attached nystatin method. Two K+ channels were found which were highly active on the cell with a conductance of 67 +/- 5 pS (n = 18) and 148 +/- 4 pS (n = 21) with 145 mmol/l K+ in the pipette. In excised patches the first channel had a conductance of 28 +/- 2 pS (n = 15), whereas the second one had a conductance of 85 +/- 1 pS (n = 53) at 0 mV clamp voltage with 145 mmol/l K+ on one side and 3.6 mmol/l K+ on the other side of the membrane. So far it has not been possible to characterize the smaller channel further. Excised, and with symmetrical K+ concentrations of 145 mmol/l, the intermediate channel had a linear conductance of 198 +/- 19 pS (n = 5). After excision in the inside-out configuration the open probability (Po) of this channel was low (0.18 +/- 0.05, n = 13) whereas in the outside-out configuration this channel had a threefold higher Po (0.57 +/- 0.04, n = 12). Several inhibitors were tested in excised membranes. Ba2+ (1 mmol/l), tetraethylammonium (TEA+, 10 mmol/l) and verapamil (0.1 mmol/l) all blocked this channel reversibly.(ABSTRACT TRUNCATED AT 250 WORDS)
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