ArticleThe Journal of clinical investigation1993
Cardiac alpha-myosin heavy chains differ in their induction of myocarditis. Identification of pathogenic epitopes.
Article in The Journal of clinical investigation, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Beyond monoclonal antibodies: constraints and the case for alternative PD-1/PD-L1-targeting formats.Frontiers in immunology · 2025Review
- Focus on Autoimmune Myocarditis in Graves' Disease: A Case-Based Review.Frontiers in cardiovascular medicine · 2021Review
- In situ detection of autoreactive CD4 T cells in brain and heart using major histocompatibility complex class II dextramers.Journal of visualized experiments : JoVE · 2014Article
- Article
- IL-21R expression on CD8+ T cells promotes CD8+ T cell activation in coxsackievirus B3 induced myocarditis.Experimental and molecular pathology · 2012Article
- Trypanosoma cruzi antigen immunization induces a higher B cell survival in BALB/c mice, a susceptible strain, compared to C57BL/6 B lymphocytes, a resistant strain to cardiac autoimmunity.Medical microbiology and immunology · 2011Article
- Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice.Experimental physiology · 2011Article
- Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.Autoimmunity · 2008Article
- Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells.The American journal of pathology · 2005Article
- Polarity of helper T cell subsets represents disease nature and clinical course of experimental autoimmune myocarditis in rats.Clinical and experimental immunology · 2003Article
- Induction of myocarditis and valvulitis in lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis.The American journal of pathology · 2002Article
- Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis.The American journal of pathology · 2001Review
- Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross-react with virus and cardiac myosin.Immunology · 1998Article
- Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein.Infection and immunity · 1997Article
- Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.The Journal of clinical investigation · 1996Article
- Myocarditis-inducing epitope of myosin binds constitutively and stably to I-Ak on antigen-presenting cells in the heart.The Journal of experimental medicine · 1995Article
- Experimental rat model representing both acute and chronic heart failure related to autoimmune myocarditis.Cardiovascular drugs and therapy · 1995Article
- Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity.The Journal of experimental medicine · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BALB/c mice develop autoimmune myocarditis after immunization with mouse cardiac myosin, whereas C57B/6 mice do not. To define the immunogenicity and pathogenicity of cardiac myosin in BALB/c mice, we immunized mice with different forms of cardiac myosin. These studies demonstrate the discordance of immunogenicity and pathogenicity of myosin heavy chains. The cardiac alpha-myosin heavy chains of BALB/c and C57B/6 mice differ by two residues that are near the junction of the head and rod in the S2 fragment of myosin. Myosin preparations from both strains are immunogenic in susceptible BALB/c as well as in nonsusceptible C57B/6 mice; however, BALB/c myosin induces a greater incidence of disease. To further delineate epitopes of myosin heavy chain responsible for immunogenicity and disease, mice were immunized with fragments of genetically engineered rat alpha cardiac myosin. Epitopes in the region of difference between BALB/c and C57B/6 (residues 735-1032) induce disease in both susceptible and nonsusceptible mice. The data presented here demonstrate that pathogenic epitopes of both mouse and rat myosin residue in the polymorphic region of the S2 subunit. In addition, these studies suggest that polymorphisms in the autoantigen may be part of the genetic basis for autoimmune myocarditis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.