ArticleNucleic acids research1995
Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues.
Article in Nucleic acids research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Ribonucleases of Mice and Men: Unveiling the Roles of the RNase A Superfamily in Host Defence.Journal of immunology research · 2025Review
- Review
- Functional Insight into hTRIR.Current molecular medicine · 2024Article
- Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer.Communications biology · 2022Article
- Expression and function of human ribonuclease 4 in the kidney and urinary tract.American journal of physiology. Renal physiology · 2021Article
- Weighted correlation network and differential expression analyses identify candidate genes associated with BRAF gene in melanoma.BMC medical genetics · 2019Article
- The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection.Frontiers in immunology · 2019Review
- The Immunomodulatory and Antimicrobial Properties of the Vertebrate Ribonuclease A Superfamily.Vaccines · 2018Review
- Immune Modulation by Human Secreted RNases at the Extracellular Space.Frontiers in immunology · 2018Review
- The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity.International journal of molecular sciences · 2016Review
- Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Extensive genetic variation in somatic human tissues.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase.Nucleic acids research · 2007Article
- Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer.British journal of cancer · 2005Article
- The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression.Nucleic acids research · 2005Article
- Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents.Journal of molecular evolution · 2004Article
- Human RNase 7: a new cationic ribonuclease of the RNase A superfamily.Nucleic acids research · 2003Article
- A gender-specific mRNA encoding a cytotoxic ribonuclease contains a 3' UTR of unusual length and structure.Nucleic acids research · 2000Article
- Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family.Nucleic acids research · 1997Article
- Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family.Nucleic acids research · 1996Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a unique genomic fragment encoding human ribonuclease 4 (RNase 4) of the mammalian ribonuclease gene family, whose members include pancreatic ribonuclease, eosinophil-derived neurotoxin, eosinophil cationic protein and angiogenin. We have determined that the coding sequence of RNase 4 resides on a single exon found on human chromosome 14. The mRNA encoding RNase 4 was detected by Northern analysis in a number of human somatic tissues, including pancreas, lung, skeletal muscle, heart, kidney and placenta, but not brain; liver represents the most abundant source. Interestingly, the mRNA encoding RNase 4 is approximately 2 kb in length, which is approximately twice as large as the mRNAs encoding other members of this gene family. A larger (approximately 2.4 kb), second transcript was detected in hepatic, pancreatic and renal tissues. The approximately 2 kb RNase 4 mRNA was detected in cells of the human promyelocytic leukemia line, HL-60, that had been treated with dibutyryl-cAMP to promote neutrophilic differentiation. In contrast, no mRNA encoding RNase 4 could be detected in cells treated with phorbol myristic acid (PMA), an agent promoting differentiation toward monocyte/macrophages, suggesting the existence of elements regulating tissue specific expression of this gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.