ArticleThe Journal of experimental medicine1995
Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 249 citations in OpenAlex.
- CCL20 and IL22 Messenger RNA Expression After Adalimumab vs Methotrexate Treatment of Psoriasis: A Randomized Clinical Trial.JAMA dermatology · 2015Trial
- Keratinocyte apoptosis in epidermal remodeling and clearance of psoriasis induced by UV radiation.The Journal of investigative dermatology · 2011Trial
- Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques.The Journal of investigative dermatology · 2010Trial
- Down-Regulation of HLA-C Expression on Melanocytes May Contribute to the Therapeutic Efficacy of UVB Phototherapy in Psoriasis.International journal of molecular sciences · 2025Article
- Narrow-Band UVB Phototherapy in the Treatment of Cutaneous Immune-Related Adverse Events From Immune Checkpoint Inhibitors: A Multicenter Retrospective Analysis.Photodermatology, photoimmunology & photomedicine · 2024Article
- Ursolic Acid Formulations Effectively Induce Apoptosis and Limit Inflammation in the Psoriasis Models In Vitro.Biomedicines · 2024Article
- Efficacy of bath-psoralen and ultraviolet A therapy for mycosis fungoides - retrospective analysis of 62 cases.The Journal of dermatology · 2022Article
- Article
- Seasonal Variation of Psoriasis and Its Impact in the Therapeutic Management: A Retrospective Study on Chinese Patients.Clinical, cosmetic and investigational dermatology · 2021Article
- A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ Cells.Frontiers in medicine · 2018Article
- Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Immunotargeting in the management of psoriasis.ImmunoTargets and therapy · 2013Review
- Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis.Dermatology research and practice · 2013Article
- Pruritus in cutaneous T-cell lymphoma: a review.Journal of the American Academy of Dermatology · 2012Review
- Light, including ultraviolet.Journal of autoimmunity · 2010Review
- Psoriasis assessment tools in clinical trials.Annals of the rheumatic diseases · 2005Review
- Immune surveillance in the skin: mechanisms and clinical consequences.Nature reviews. Immunology · 2004Review
- Immunopathogenic mechanisms in psoriasis.Clinical and experimental immunology · 2004Review
- Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors.The Journal of experimental medicine · 2000Article
- Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?Clinical and experimental immunology · 1999Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Skin irradiation with ultraviolet B (UVB) is a common and often durable treatment for psoriasis and other inflammatory skin disorders. We studied the effects of UVB on keratinocytes and leukocytes in psoriatic tissue and in culture. In nine patients treated repetitively, most of the cellular and molecular changes that typify the psoriatic epidermis reverted to normal. Keratinocyte hyperplasia, assessed by expression of the Ki-67 cell cycle antigen, decreased by 70%, and residual cell proliferation was appropriately confined to the basal layer. Epidermal thickening was reduced by 60%, and a granular layer reformed. Expression of keratin 16, as well as suprabasal integrin alpha 3 and insulin-like growth factor-1 receptors, was eliminated, whereas filagrin increased markedly. UVB also depleted > 90% of the CD3+, CD8+, and CD25+ T cells from the psoriatic epidermis, whereas dermal T cells were only minimally depressed. The latter finding parallels the known inability of these doses of UVB to penetrate the dermis. In tissue culture, UVB was antiproliferative and cytotoxic toward T cells and keratinocytes, but the T cells were 10-fold more sensitive. Furthermore, low doses of UVB induced apoptosis in lymphocytes but not keratinocytes, as detected by the TUNEL (TdT-mediated dUTP-biotin nick end labeling) technique. The selective effects of UVB on intraepidermal T cells in situ and in culture support the hypothesis that epidermal alterations in psoriasis can be normalized by a depletion of activated intraepidermal T cells.
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