ArticleThe Journal of experimental medicine1995
The peptide-binding motif for the human transporter associated with antigen processing.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 181 citations in OpenAlex.
- Preclinical efficacy of dendritic cells loaded with newly identified HPV11 E6-derived CD8NPJ vaccines · 2026Article
- Principles of peptide selection by the transporter associated with antigen processing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Prediction of TAP Transport of Peptides with Variable Length Using TAPREG.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase.Nature communications · 2022Article
- Epitope length variants balance protective immune responses and viral escape in HIV-1 infection.Cell reports · 2022Article
- The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities.Frontiers in immunology · 2022Article
- Current and prospective computational approaches and challenges for developing COVID-19 vaccines.Advanced drug delivery reviews · 2021Review
- Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking.Communications biology · 2021Article
- Understanding the Pathogenesis of Spondyloarthritis.Biomolecules · 2020Review
- Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).Molecular & cellular proteomics : MCP · 2020Article
- Systems Immunology: Learning the Rules of the Immune System.Annual review of immunology · 2018Review
- Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules.BMC evolutionary biology · 2018Article
- How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins.Frontiers in immunology · 2018Review
- Structure and Dynamics of Antigenic Peptides in Complex with TAP.Frontiers in immunology · 2017Review
- Structure of the transporter associated with antigen processing trapped by herpes simplex virus.eLife · 2016Article
- Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation.Scientific reports · 2016Article
- ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.Scientific reports · 2016Article
- Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1).Molecular & cellular proteomics : MCP · 2014Article
- Assembly and function of the major histocompatibility complex (MHC) I peptide-loading complex are conserved across higher vertebrates.The Journal of biological chemistry · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presentation of antigenic peptides by human leukocyte antigen class I molecules is dependent on peptide transport into the endoplasmic reticulum by the transporters associated with antigen processing (TAP) (Germain, R. N. 1994. Cell. 76:287-299). This translocation step is currently regarded as permissive for all peptides with COOH-terminal residues capable of binding to HLA class I molecules (Momburg, F., J. Roelse, J. C. Howard, G. W. Butcher, G.J. Hämmerling, and J.J. Neefjes. 1994. Nature (Lond.). 367:648-651). In this report, we show that the human transporter selects peptides according to a binding motif based on the strong effects on peptide affinity of the three NH2-terminal positions and the COOH-terminal residues. TAP favors strongly hydrophobic residues in position 3 (P3) and hydrophobic or charged residues in P2, whereas aromatic or acidic residues in P1, as well as Pro in P1 and P2, have strong deleterious effects. Selection of naturally presented peptides by the transporter is suggested by their higher average affinity for TAP, as compared to nonselected peptides. The TAP preferences in the three NH2-terminal positions correspond to those of the vast majority of human leukocyte antigen class I alleles, but they represent an obstacle for peptide supply to some alleles, e.g., the B7-like group. We propose that peptides binding to these alleles, and in general, peptides with TAP affinities below a certain threshold, may be transported as extended precursors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.