ArticleJournal of cancer research and clinical oncology1995
Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma.
Article in Journal of cancer research and clinical oncology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Characteristics of malignant thyroid lesions on [European journal of radiology open · 2021Article
- The Role ofFrontiers in endocrinology · 2019Article
- Histological and ultrastructural alterations of rat thyroid gland after short-term treatment with high doses of thyroid hormones.Saudi journal of biological sciences · 2017Article
- Radiation signatures in childhood thyroid cancers after the Chernobyl accident: possible roles of radiation in carcinogenesis.Cancer science · 2015Review
- Pathologic spectrum of lymphocytic infiltration and recurrence of papillary thyroid carcinoma.Yonsei medical journal · 2014Article
- Clinical, genetic, and immunohistochemical characterization of 70 Ukrainian adult cases with post-Chornobyl papillary thyroid carcinoma.European journal of endocrinology · 2012Article
- Well-differentiated thyroid carcinoma with concomitant Hashimoto's thyroiditis present with less aggressive clinical stage and low recurrence.Endocrine pathology · 2011Article
- Expression of DNA repair proteins MSH2, MLH1 and MGMT in human benign and malignant thyroid lesions: an immunohistochemical study.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- The role of 18F-fluorodeoxyglucose positron emission tomography in thyroid neoplasms.The oncologist · 2011Review
- p27 Kip1 protein expression in Hashimoto's thyroiditis.Journal of clinical pathology · 2003Article
- Frequency and Distribution of DNA fragmentation in Hashimoto's thyroiditis and development of papillary thyroid carcinoma.Endocrine pathology · 1999Article
- Proliferative activity of oxyphilic (Hurthle) cells in reactive and neoplastic thyroid lersions.Endocrine pathology · 1999Article
- Significant correlation of telomerase activity in thyroid papillary carcinomas with cell differentiation, proliferation and extrathyroidal extension.Japanese journal of cancer research : Gann · 1997Article
- Bcl-2 is closely correlated with favorable prognostic factors and inversely associated with p53 protein accumulation in endometrial carcinomas: immunohistochemical and polymerase chain reaction/loss of heterozygosity findings.Journal of cancer research and clinical oncology · 1997Article
- The Relationship of Lymphocytic Thyroiditis to the Development of Thyroid Carcinoma.Endocrine pathology · 1997Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the analysis of cellular proliferative activity and cell death in thyroid diseases, the Ki-67 labeling index, bcl-2 protein expression and cell death of follicular epithelia by immunohistochemistry and in situ DNA nick-end labeling methods were evaluated in normal thyroid tissues as well as in surgical specimens from cases of Hashimoto's disease (16 cases), focal lymphocytic thyroiditis (13 cases), Graves' disease (15 cases), follicular adenoma (20 cases) and papillary carcinoma (43 cases). Cellular proliferative activity and cell death were both enhanced in cases of thyroiditis, including Hashimoto's disease and focal lymphocytic thyroiditis. Thyroids from patients with follicular adenoma and papillary carcinoma also showed increased cellular proliferative activity and cell death. In addition, predominant high cellularity and partial loss of bcl-2 protein expression in papillary carcinoma suggested that the overgrowth and dedifferentiation were associated with malignancy.
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