ArticleGenetics1995
Mutational analysis of morphologic differentiation in Saccharomyces cerevisiae.
Article in Genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Translational Reprogramming Provides a Blueprint for Cellular Adaptation.Cell chemical biology · 2018Article
- Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function.Cell cycle (Georgetown, Tex.) · 2016Article
- Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress.Molecular cell · 2015Article
- Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis.Biological chemistry · 2011Article
- Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources.Molecular and cellular biology · 2010Article
- Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth.Current genetics · 2009Article
- A novel genetic screen implicates Elm1 in the inactivation of the yeast transcription factor SBF.PloS one · 2008Article
- Glucose signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2006Review
- Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast.The EMBO journal · 2005Article
- Glucose inhibits meiotic DNA replication through SCFGrr1p-dependent destruction of Ime2p kinase.Molecular and cellular biology · 2005Article
- Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways.Molecular and cellular biology · 2004Article
- Genetic interactions among regulators of septin organization.Eukaryotic cell · 2004Article
- Control of yeast filamentous-form growth by modules in an integrated molecular network.Genome research · 2004Article
- Meiotic differentiation during colony maturation in Saccharomyces cerevisiae.Current genetics · 2002Article
- Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Hyphal elongation is regulated independently of cell cycle in Candida albicans.Molecular biology of the cell · 2002Article
- Article
- Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p.Molecular biology of the cell · 2001Article
- A role for the Swe1 checkpoint kinase during filamentous growth of Saccharomyces cerevisiae.Genetics · 2001Article
- F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A genetic analysis was undertaken to investigate the mechanisms controlling cellular morphogenesis in Saccharomyces cerevisiae. Sixty mutant strains exhibiting abnormally elongated cell morphology were isolated. The cell elongation phenotype in at least 26 of the strains resulted from a single recessive mutation. These mutations, designated generically elm (elongated morphology), defined 14 genes; two of these corresponded to the previously described genes GRR1 and CDC12. Genetic interactions between mutant alleles suggest that several ELM genes play roles in the same physiological process. The cell and colony morphology and growth properties of many elm mutant strains are similar to those of wild-type yeast strains after differentiation in response to nitrogen limitation into the pseudohyphal form. Each elm mutation resulted in multiple characteristics of pseudohyphal cells, including elongated cell shape, delay in cell separation, simultaneous budding of mother and daughter cells, a unipolar budding pattern, and/or the ability to grow invasively beneath the agar surface. Mutations in 11 of the 14 ELM gene loci potentiated pseudohyphal differentiation in nitrogen-limited medium. Thus, a subset of the ELM genes are likely to affect control or execution of a defined morphologic differentiation pathway in S. cerevisiae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.