ArticleAnnals of the rheumatic diseases1995
Increased levels of serum IgM antibody to staphylococcal enterotoxin B in patients with rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Blocking Superantigen-Mediated Diseases: Challenges and Future Trends.Journal of immunology research · 2024Review
- Superantigens, a Paradox of the Immune Response.Toxins · 2022Review
- Assay of Blood and Synovial Fluid of Patients With Rheumatoid Arthritis for Staphylococcus aureus Enterotoxin D: Absence of Bacteria But Presence of Its Toxin.Jundishapur journal of microbiology · 2015Article
- Bacteriological and molecular assessment of staphylococcal enterotoxin e in the blood of patients with rheumatoid arthritis.Jundishapur journal of microbiology · 2015Article
- Staphylococcal enterotoxin C in synovial fluid of patients with rheumatoid arthritis.Iranian Red Crescent medical journal · 2014Article
- Therapeutic down-modulators of staphylococcal superantigen-induced inflammation and toxic shock.Toxins · 2010Review
- Article
- Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis.Clinical and experimental immunology · 2003Article
- Effects of staphylococcal enterotoxins on human neutrophil functions and apoptosis.Infection and immunity · 1999Article
- CD4+ T-cell-mediated cytotoxicity against staphylococcal enterotoxin B-pulsed synovial cells.Immunology · 1998Article
- Staphylococcus aureus nasal carriage in rheumatoid arthritis: antibody response to toxic shock syndrome toxin-1.Annals of the rheumatic diseases · 1996Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the role of superantigen in rheumatoid arthritis (RA) by assaying the serum levels of staphylococcal enterotoxin B (SEB) antibodies.
methodsSerum IgG and IgM SEB antibodies were measured using an enzyme linked immunosorbent assay (ELISA), and confirmed by Western blot analysis. The T cell receptor V beta (TCR V beta) repertoire was analysed using the reverse transcriptase polymerase chain reaction.
resultsRA patients had increased levels of serum IgM SEB antibody compared with normal subjects, patients with systemic lupus erythematosus, Sjögren's syndrome, and Behçet's disease. The titres of rheumatoid factor (RF) showed no correlation with the levels of IgM SEB antibodies, and the levels of SEB antibodies were not inhibited by the addition of human immunoglobulin, or after absorption of RF. RA patients whose disease duration was less than 10 years had greater levels of serum IgM SEB antibodies than those with disease duration more than 10 years. The levels of IgM and IgG SEB antibodies in synovial fluid from RA patients were correlated with those in their sera. Western blot analysis detected IgM and IgG SEB antibodies as a band of approximately 30 kDa molecular size. The percentage of TCR V beta 2, V beta 5.2, and V beta 12 in phytohaemagglutinin stimulated peripheral T cells correlated significantly with the levels of serum IgM SEB antibody in RA patients.
conclusionThese results suggest that SEB, one of the superantigens, may have a critical role in the pathogenesis of RA.
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