ArticleThe American journal of pathology1995
Insulin-like growth factor II in the pathogenesis of human neuroblastoma.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Convergent IGF2 overexpression in pheochromocytoma/paraganglioma: insights from Beckwith-Wiedemann syndrome.Endocrine-related cancer · 2026Article
- The role of insulin-like growth factor I-II receptor on development of pleomorphic adenoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Cell survival signaling in neuroblastoma.Anti-cancer agents in medicinal chemistry · 2013Review
- Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.Pediatric blood & cancer · 2012Article
- Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.Molecular cancer · 2010Article
- Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.Journal of cellular biochemistry · 2007Article
- Mouse models of diabetic neuropathy.Neurobiology of disease · 2007Article
- N-Myc overexpression leads to decreased beta1 integrin expression and increased apoptosis in human neuroblastoma cells.Oncogene · 2003Article
- Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells.British journal of cancer · 2001Article
- Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis models.British journal of cancer · 2000Article
- Up-regulation of insulin-like growth factor-II expression is a feature of TrkA but not TrkB activation in SH-SY5Y neuroblastoma cells.The American journal of pathology · 1999Article
- Pituitary Insulin: Insulin-Like Growth Factors.Endocrine pathology · 1997Article
- Adrenal Medullary Nodules in Beckwith-Wiedemann Syndrome Resemble Extra-Adrenal Paraganglia.Endocrine pathology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Insulin-like growth factor II (IGF-II) acts as an autocrine growth factor for many in vitro tumor cell lines including neuroblastoma. To examine the role of IGF-II in tumor biology we have analyzed a total of 56 primary neuroblastoma tumor samples for the presence of IGF-II using a combination of mRNA and protein analysis. A group of 21 samples was examined for the presence of IGF-II mRNA by slot blot and a separate group of 37 samples was examined for IGF-II immunoreactivity. IGF-II was detected in 48% of the total tumor specimens analyzed. IGF-II immunoreactivity was observed in cells resembling developing neuroblasts and was confined to the cytoplasm and proximal neurites. The appearance of IGF-II mRNA and protein did not correlate with tumor prognostic features including stage, histology, or N-myc amplification. These data suggest that the expression of IGF-II is not confined to a specific stage of the disease but may have a broader role in the pathogenesis of neuroblastoma.
Indexed as
Identifiers
7495303PMC1869938W282758479What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.