ArticleThe American journal of pathology1995
Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 178 citations in OpenAlex.
- Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives.Signal transduction and targeted therapy · 2025Review
- Effect of Everolimus versus Bone Marrow-Derived Stem Cells on Glomerular Injury in a Rat Model of Glomerulonephritis: A Preventive, Predictive and Personalized Implication.International journal of molecular sciences · 2021Article
- LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure.Cell death & disease · 2021Article
- Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti-Thy-1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway.Cell proliferation · 2021Article
- Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.Scientific reports · 2020Article
- Protective effect of vascular endothelial growth factor against cardiopulmonary bypass-associated acute kidney injury in beagles.Experimental and therapeutic medicine · 2018Article
- Article
- Dual Role of MiR-21-Mediated Signaling in HUVECs and Rat Surgical Flap under Normoxia and Hypoxia Condition.International journal of molecular sciences · 2017Article
- Extrarenal Progenitor Cells Do Not Contribute to Renal Endothelial Repair.Journal of the American Society of Nephrology : JASN · 2016Article
- Platelets are relevant mediators of renal injury induced by primary endothelial lesions.American journal of physiology. Renal physiology · 2015Article
- miR-21 in ischemia/reperfusion injury: a double-edged sword?Physiological genomics · 2014Review
- New insights into molecular mechanisms of diabetic kidney disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2014Review
- A new apparatus for standardized rat kidney biopsy.PloS one · 2014Article
- Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.Cardiovascular & hematological disorders drug targets · 2014Review
- Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy.PloS one · 2013Article
- Low proliferative potential and impaired angiogenesis of cultured rat kidney endothelial cells.Microcirculation (New York, N.Y. : 1994) · 2012Article
- ACE Inhibition in Anti-Thy1 Glomerulonephritis Limits Proteinuria but Does Not Improve Renal Function and Structural Remodeling.Nephron extra · 2012Article
- The effects of PTK787/ZK222584, an inhibitor of VEGFR and PDGFRβ pathways, on intussusceptive angiogenesis and glomerular recovery from Thy1.1 nephritis.The American journal of pathology · 2011Article
- Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1.The American journal of pathology · 2011Article
- Lack of collagen XVIII/endostatin exacerbates immune-mediated glomerulonephritis.Journal of the American Society of Nephrology : JASN · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
In many glomerular diseases severe injury to the mesangium may occur, leading to matrix dissolution and damage to the glomerular capillaries. Although the destruction of glomerular architecture may lead to permanent injury, in some cases spontaneous recovery occurs. The mechanisms that mediate this recovery are unknown. In this study we provide evidence for glomerular capillary repair (angiogenesis) in the adult injured glomerulus. Injection of anti-Thy 1 antibody into rats results in severe mesangiolysis with capillary ballooning, microaneurysm formation, and loss of endothelial cells in addition to mesangial cells. Although mesangial proliferation is a major response to injury, proliferation of endothelial cells also can be documented from days 2 to 14 in association with repair of the capillaries. The endothelial cell proliferation peaks on days 2 and 7, when it is seven- to ninefold greater than normal. Many of the endothelial cells display morphological features of angiogenesis. The initial wave of endothelial cell proliferation can be reduced by 40% with neutralizing anti-basic fibroblast growth factor antibodies (P < 0.001). The later glomerular endothelial cell proliferation is associated with upregulated expression of vascular permeability factor/endothelial cell growth factor (VPF/VEGF) and an increase of flk, a VPF/VEGF receptor. Although PDGF is expressed in this model, anti-PDGF antibody treatment did not affect the endothelial cell proliferative response. In summary, glomerular endothelial cells have an active role in the glomerular response to injury. Glomeruli are capable of healing microaneurysms, and the mechanism involves basic fibroblast growth factor- and VPF/VEGF-mediated endothelial proliferative responses.
Indexed as
Identifiers
7495296PMC1869935W1932581309What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.