ArticleThe American journal of pathology1995
Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 50 citations in OpenAlex.
- Amplification and protein expression of androgen receptor gene in prostate cancer cells: FluorescenceOncology letters · 2015Article
- Experimental evidence of persistent androgen-receptor-dependency in castration-resistant prostate cancer.International journal of molecular sciences · 2013Review
- Predicting response to hormonal therapy and survival in men with hormone sensitive metastatic prostate cancer.Critical reviews in oncology/hematology · 2013Review
- Article
- Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients.Journal of Zhejiang University. Science. B · 2007Article
- Molecular staging of prostate cancer in the year 2007.World journal of urology · 2007Review
- Mithramycin targets sp1 and the androgen receptor transcription level-potential therapeutic role in advanced prostate cancer.Translational oncogenomics · 2006Article
- Somatic instability of the DNA sequences encoding the polymorphic polyglutamine tract of the AIB1 gene.Journal of medical genetics · 2003Article
- Genetic alterations in hormone-refractory recurrent prostate carcinomas.The American journal of pathology · 1998Article
- Androgen receptor gene and hormonal therapy failure of prostate cancer.The American journal of pathology · 1998Review
- Androgen-independent prostate cancer: potential role of androgen and ErbB receptor signal transduction crosstalk.Neoplasia (New York, N.Y.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms and genetic changes that lead to the progression of prostate cancer during endocrine therapy are poorly characterized. Here, paired specimens from both untreated primary tumors and from local recurrences were collected from 10 prostate cancer patients treated by conventional androgen deprivation therapy. The genetic progression of the tumors was studied by using interphase fluorescence in situ hybridization and chromosome-specific probes. Six primary tumors (60%) and all ten recurrent tumors were aneuploid by fluorescence in situ hybridization. The recurrent tumors also showed a high degree of chromosome copy number variability from one cell to another. Increased copy number of chromosome X was particularly common in the recurrent tumors. In addition, specific high level amplification of the androgen receptor (AR) gene (Xq12) was detected in three highly aneuploid recurrent tumors. Our findings suggest that hormone-refractory prostate cancers are genetically very complex and show intratumor genetic heterogeneity. Increased copy number of chromosome X and the amplification of the androgen receptor (AR) gene may confer proliferative advantage during androgen deprivation and thus contribute to the development of recurrence.
Indexed as
Identifiers
7495286PMC1869969W135558962What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.