ArticleThe American journal of pathology1995
Apolipoprotein(a) deposition in atherosclerotic plaques of cerebral vessels. A potential role for endothelial cells in lesion formation.
Article in The American journal of pathology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Lipoprotein (a) as a risk factor for prosthetic heart valve thrombosis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Assessing causal associations of blood counts and biochemical indicators with pulmonary arterial hypertension: a Mendelian randomization study and results from national health and nutrition examination survey 2003-2018.Frontiers in endocrinology · 2024Observational
- Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Scavenger receptor-BI is a receptor for lipoprotein(a).Journal of lipid research · 2013Article
- Lipoprotein(a): biology and clinical importance.The Clinical biochemist. Reviews · 2004Article
- Changing patterns in the neuropathogenesis of HIV during the HAART era.Brain pathology (Zurich, Switzerland) · 2003Review
- Lipoprotein(a) and the atherothrombotic process: mechanistic insights and clinical implications.Current atherosclerosis reports · 2003Review
- Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus.Journal of virology · 2000Article
- Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.The Journal of clinical investigation · 1998Article
- The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor.The Journal of clinical investigation · 1997Article
- CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.The American journal of pathology · 1997Article
- Subendothelial retention of lipoprotein (a). Evidence that reduced heparan sulfate promotes lipoprotein binding to subendothelial matrix.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is the leading cause of death and serious morbidity in economically developed societies through its sequelae of coronary artery and cerebrovascular disease. The causes and mechanisms of atherosclerosis are still largely unknown. Serum levels of a lipoprotein, Lp(a), have been shown, in retrospective and some prospective clinical studies, to be associated with increased risk of myocardial and cerebral infarction. The active part of Lp(a), apo(a), has > 80% homology with plasminogen; thus it may competitively inhibit the thrombolytic action of plasminogen and enhance thrombogenesis. Lp(a) has been shown to be deposited in the vascular wall of the aorta and coronary vessels, but its presence in the cerebral vessels has not yet been shown. Autopsy specimens of vessels of the circle of Willis from 23 patients were examined for degree of atherosclerosis and deposition of apo(a) by immunohistochemistry with apo(a)-specific monoclonal antibodies. The amount of apo(a) deposition in cerebral vessels correlated well with the degree of cerebral atherosclerosis. Arterial deposition of apo(a) was found entirely within the endothelial cell and subendothelial cell layers. There was no staining within the media and adventitia, with the exception of staining within the endothelial cells of the vasa vasorum. Correlation between the morphology of apo(a) deposition and plaque stage was found suggesting that detection of apo(a) in endothelial cells is an early event in the development of the atherosclerotic plaque of cerebral vessels.
Indexed as
Identifiers
7495281PMC1869946W284943613What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.