ReviewOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1995
The search for missing links between self-replicating nucleic acids and the RNA world.
Review in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- On the Uniqueness of the Standard Genetic Code.Life (Basel, Switzerland) · 2017Article
- The role of natural selection in the origin of life.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Review
- On the evolution of the standard genetic code: vestiges of critical scale invariance from the RNA world in current prokaryote genomes.PloS one · 2009Article
- Conditions for the emergence of life on the early Earth: summary and reflections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Article
- The scene of a frozen accident.RNA (New York, N.Y.) · 2000Article
- Use of DNA, RNA, and chimeric templates by a viral RNA-dependent RNA polymerase: evolutionary implications for the transition from the RNA to the DNA world.Journal of virology · 1999Article
- The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.Pharmacology & therapeutics · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The notion that modern metabolism was derived from a complex 'RNA world' in which most reactions were catalyzed by ribozymes has received wide acceptance. However, the evolutionary links between the first self-replicating systems and ribozymes as complex as, say, the Group I self-splicing intron or the HDV ribozyme, have remained elusive. While prebiotic chemists have succeeded in synthesizing short oligonucleotides, it is not immediately obvious how these could have replicated and evolved to the point where they could assume complex shapes and catalytic functions. Nonetheless, recent experiments from a variety of disciplines suggest a plausible pathway from prebiotic chemistry to complex metabolism, and this review is intended as a hypothetical roadmap for the origin and subsequent evolution of life.
Indexed as
Identifiers
7494634What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.