Evidence map›Paper›PMID 7494344›Full record

ArticleJournal of virology1995

The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.

J B Mannick, X Tong, A Hemnes, E Kieff

Abstract readComparative Study
In one paragraph

Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Epstein-Barr virus latent genes.Experimental & molecular medicine · 2015
    Review
  4. Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J B MannickDepartment of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA.
X Tong
A Hemnes
E Kieff

Funding

Epstein-Barr Virus Nuclear Proteins in B Cell Growth TransformationR01CA047006 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHAO, BO · 2002 to 2021
$12.1M
MOLECULAR BIOLOGY OF EPSTEIN-BARR VIRUS INFECTIONR35CA047006 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI KIEFF, ELLIOTT D · 1987 to 2000
$1.6M
ROLE OF EBNA-LP IN EBV-INDUCED TRANSFORMATIONK11AI000996 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MANNICK, JOAN B · 1990 to 1994
–
NCI NIH HHS CA47006NIAID NIH HHS AI00996-01
6 · The paper itself

Abstract

Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation. We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed interaction between EBNA-LP and the retinoblastoma protein or p53.

Indexed as

HSP70 Heat-Shock ProteinsAmino Acid SequenceAntigens, ViralB-LymphocytesCell LineDNA-Binding ProteinsElectrophoresis, Polyacrylamide GelEpstein-Barr Virus Nuclear AntigensGene ExpressionHeat-Shock ProteinsHSC70 Heat-Shock ProteinsHSP72 Heat-Shock ProteinsHumansLymphocyte ActivationMethionineMolecular Sequence DataAntigens, ViralDNA-Binding ProteinsEpstein-Barr Virus Nuclear AntigensHeat-Shock ProteinsHSC70 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHSP72 Heat-Shock ProteinsHSPA8 protein, humanMethionineRecombinant ProteinsRetinoblastoma ProteinTrans-ActivatorsTumor Suppressor Protein p53

Identifiers

PMID7494344
PMCPMC189776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.