ArticleJournal of virology1995
CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 103 citations in OpenAlex.
- Role of cytotoxic T lymphocytes and interferon-γ in coronavirus infection: Lessons from murine coronavirus infections in mice.The Journal of veterinary medical science · 2020Review
- Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Microglia are required for protection against lethal coronavirus encephalitis in mice.The Journal of clinical investigation · 2018Article
- Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus.Journal of neurovirology · 2017Article
- MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis.Journal of virology · 2016Article
- MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.Journal of virology · 2015Article
- The cellular redox environment alters antigen presentation.The Journal of biological chemistry · 2014Article
- Identification of novel functional regions within the spike glycoprotein of MHV-A59 based on a bioinformatics approach.Virus research · 2014Article
- Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages.PLoS pathogens · 2014Article
- IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.Journal of virology · 2011Article
- Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection.Experimental neurology · 2010Article
- Genetic determinants of mouse hepatitis virus strain 1 pneumovirulence.Journal of virology · 2010Article
- A protective role for ELR+ chemokines during acute viral encephalomyelitis.PLoS pathogens · 2009Article
- De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination.Autoimmunity · 2009Article
- Characterization of cytotoxic T-lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD-integrin-binding motif.Journal of medical virology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CD8+ T cells with cytotoxic activity against the surface glycoprotein (S) of mouse hepatitis virus, strain JHM, have been identified in the central nervous system (CNS) of both acutely and chronically infected C57BL/6 mice. In this report, two specific epitopes recognized by these CNS-derived cells were identified, using a panel of peptides chosen because they conformed to the allele-specific binding motif for MHC class I H-2Kb and H-2Db. The active peptides encompassed residues 510 to 518 (CSLWNGPHL, H-2Db) and 598 to 605 (RCQIFANI, H-2Kb). Both epitopes are located within the region of the S protein previously shown to be prone to deletion after passage in animals. These deleted strains are generally less neurovirulent than the wild-type virus but still are able to cause demyelination. Since C57BL/6 mice become persistently infected more commonly than many other strains of mice, these data are consistent with a role for CD8+ T-cell escape mutants in the pathogenesis of the demyelinating disease. This is the first report of CD8+ T-cell epitope localization within the S protein, the protein most strongly implicated thus far in pathogenesis in the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.