ArticleJournal of virology1995
E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling.Cell host & microbe · 2017Article
- Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP.Protein science : a publication of the Protein Society · 2016Article
- The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.Journal of molecular biology · 2014Article
- Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.Cell host & microbe · 2014Article
- Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics.Journal of virology · 2013Article
- Article
- Different regions of the HPV-E7 and Ad-E1A viral oncoproteins bind competitively but through distinct mechanisms to the CH1 transactivation domain of p300.Biochemistry · 2012Article
- Article
- Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.Journal of virology · 2008Review
- TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members.Biochimica et biophysica acta · 2007Article
- Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.Oncogene · 2007Article
- Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300.Journal of virology · 1999Article
- Polyomavirus large T antigen binds the transcriptional coactivator protein p300.Journal of virology · 1999Article
- Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.Molecular and cellular biology · 1998Article
- Expression of the pRb-binding regions of E1A enables efficient transformation of primary epithelial cells by v-src.Journal of virology · 1998Article
- A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans.Genes & development · 1998Article
- Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The oncogenes of the small DNA tumor viruses encode transforming proteins with multiple domains that influence the cell cycle and aspects of the transformed phenotype. Like other gene products of this type, the adenovirus E1A proteins influence the cell by binding to specific cell growth control proteins. These include members of the retinoblastoma gene product (pRB) family, which are bound by the E1A region 2-specific site, and p300, which is bound at the E1A amino terminus. Binding at these two sites is largely independent, and discrete transcription-regulating functions remain intact in E1A products when only one or the other binding site is functional. In this report, immunoprecipitation with p300 antibodies reveals the presence of the pRB family proteins in p300 complexes when E1A is expressed in host cells, indicating that E1A can mediate physical contact between p300 and the pRB-related proteins. The ability of E1A to induce proliferation efficiently in quiescent primary cells correlates closely with the ability to bind p300 and individual members of the pRB family simultaneously in multimeric complexes, even though the E1A active sites can bind their target proteins efficiently when separated on different molecules. Conservation of a spacer region between the two binding sites that is required for simultaneous binding and efficient induction of proliferation supports the concept that the E1A protein structure has evolved to facilitate simultaneous binding. These results indicate that the E1A proteins are designed not merely to sequester these cellular products, but also to bring them into proximal association with each other in biologically significant complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.