ArticleJournal of virology1995
Plus-strand strong-stop DNA synthesis in retrotransposon Ty1.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Novel transcript truncating function of Rap1p revealed by synthetic codon-optimized Ty1 retrotransposon.Genetics · 2012Article
- Ty1 reverse transcriptase does not read through the proposed 2',5'-branched retrotransposition intermediate in vitro.RNA (New York, N.Y.) · 2007Article
- Mn2+ suppressor mutations and biochemical communication between Ty1 reverse transcriptase and RNase H domains.Journal of virology · 2007Article
- DBR1 siRNA inhibition of HIV-1 replication.Retrovirology · 2005Article
- Functional genomics reveals relationships between the retrovirus-like Ty1 element and its host Saccharomyces cerevisiae.Genetics · 2003Article
- A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity.Journal of virology · 2002Article
- In vivo Ty1 reverse transcription can generate replication intermediates with untidy ends.Journal of virology · 1998Article
- Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus.The EMBO journal · 1998Article
- Extended minus-strand DNA as template for R-U5-mediated second-strand transfer in recombinational rescue of primer binding site-modified retroviral vectors.Journal of virology · 1998Article
- Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo.Molecular and cellular biology · 1998Article
- Replication errors during in vivo Ty1 transposition are linked to heterogeneous RNase H cleavage sites.Molecular and cellular biology · 1998Article
- Plus-strand strong-stop DNA transfer in yeast Ty retrotransposons.The EMBO journal · 1997Article
- Heterogeneous terminal structure of Ty1 and Ty3 reverse transcripts.Nucleic acids research · 1997Article
- Retrovirus-like end processing of the tobacco Tnt1 retrotransposon linear intermediates of replication.Journal of virology · 1997Article
- Increased length of long terminal repeats inhibits Ty1 transposition and leads to the formation of tandem multimers.Genetics · 1997Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Reverse transcription in the yeast retrotransposon Ty1 follows the general "rules" of retroviral replication overall. However, some details of the retroviral and Ty1 reverse transcription processes are different. We have identified and determined the structure of plus-strand strong-stop DNA and examined the effect of polypurine tract deletion mutations on its synthesis. Furthermore, we have defined the stop signal for plus-strand strong-stop DNA synthesis as an unusual 2'-O-ribosylated nucleotide in the primer tRNA. Full-length plus-strand strong-stop DNA, following strand transfer, would have a terminal 2-base mismatch with minus-strand DNA. These findings indicate that the mechanism of plus-strand strong-stop DNA transfer in Ty1 differs from that of the retroviral transfer and suggest that full-length plus-strand strong-stop DNA is not a direct intermediate in Ty1 retrotransposition.
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Registered trials
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