ArticleJournal of clinical microbiology1995
In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae.
Article in Journal of clinical microbiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 192 citations in OpenAlex.
- Seropositivity against Chlamydia pneumoniae in patients with coronary atherosclerosis.Clinical cardiology · 2000Trial
- Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or PulmonaryMicroorganisms · 2020Review
- Low-Dose Aspirin May Prevent Trophoblast Dysfunction in Women With Chlamydia Pneumoniae Infection.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis.Journal of the American College of Cardiology · 2018Article
- An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis.Journal of clinical medicine research · 2017Review
- A Zebrafish Model forFrontiers in microbiology · 2016Article
- Unraveling the environmental and genetic interactions in atherosclerosis: Central role of the gut microbiota.Atherosclerosis · 2015Review
- Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae: Possible Role in the Entry into Its Host Cells.Interdisciplinary perspectives on infectious diseases · 2014Article
- Atherosclerosis Induced by Chlamydophila pneumoniae: A Controversial Theory.Interdisciplinary perspectives on infectious diseases · 2013Article
- Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis.Journal of translational medicine · 2012Article
- Chlamydia pneumoniae infection in polarized epithelial cell lines.Infection and immunity · 2010Article
- Amalgamation of Chlamydia pneumoniae inclusions with lipid droplets in foam cells in human atherosclerotic plaque.Virchows Archiv : an international journal of pathology · 2008Article
- Retinoic acid inhibits the infectivity and growth of Chlamydia pneumoniae in epithelial and endothelial cells through different receptors.Microbial pathogenesis · 2008Article
- Degradation of Chlamydia pneumoniae by peripheral blood monocytic cells.Infection and immunity · 2005Article
- Chlamydia pneumoniae augments the oxidized low-density lipoprotein-induced death of mouse macrophages by a caspase-independent pathway.Infection and immunity · 2005Article
- Matrix metalloproteinase-9 expression is associated with the presence of Chlamydia pneumoniae in human coronary atherosclerotic plaques.Heart (British Cardiac Society) · 2005Article
- Amphiphysin IIm is required for survival of Chlamydia pneumoniae in macrophages.The Journal of experimental medicine · 2004Article
- Effects of fluoroquinolones on the migration of human phagocytes through Chlamydia pneumoniae-infected and tumor necrosis factor alpha-stimulated endothelial cells.Antimicrobial agents and chemotherapy · 2004Article
- Chlamydia pneumoniae activates epithelial cell proliferation via NF-kappaB and the glucocorticoid receptor.Infection and immunity · 2003Article
- Acute coronary disease Athero-Inflammation: Therapeutic approach.Thrombosis journal · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chlamydia pneumoniae is a common respiratory pathogen. Recent studies have demonstrated the presence of C. pneumoniae in coronary and aortic atherosclerotic lesions. To study the role of C. pneumoniae in atherosclerosis, we investigated the susceptibilities of three different cells of the human vascular wall to infection with C. pneumoniae AR-39. These cell types were endothelial cells, smooth muscle cells, and macrophages derived from peripheral blood monocytes. Infection was assessed by using a direct fluorescent antibody to assess inclusion counts. Duplicate cell samples were harvested 3 days postinfection and were passed in HL cells, a susceptible human epithelial cell line, to determine if infectious organisms were produced. Endothelial cells, smooth muscle cells, and macrophages were capable of supporting C. pneumoniae growth in vitro. These results showed that three different cell types known to be important in atherogenesis are susceptible to infection with C. pneumoniae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.