ArticleThe Journal of biological chemistry1995
Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells.
Article in The Journal of biological chemistry, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 60 citations in OpenAlex.
- Molecular mechanism of MLCK1 inducing 5-Fu resistance in colorectal cancer cells through activation of TNFR2/NF-κB pathway.Discover oncology · 2024Article
- Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium.The Journal of biological chemistry · 2012Article
- Ontogenesis of myosin light chain kinase mRNA and protein content in guinea pig tracheal smooth muscle.Pediatric pulmonology · 2004Article
- 220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns.American journal of physiology. Cell physiology · 2002Article
- Myosin ii light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1.The Journal of biological chemistry · 2001Article
- Localization and activity of myosin light chain kinase isoforms during the cell cycle.The Journal of cell biology · 2000Article
- Alterations in expression of myosin and myosin light chain kinases in response to vascular injury.American journal of physiology. Cell physiology · 2000Article
- A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes.The Journal of cell biology · 1998Article
- LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain.The Journal of cell biology · 1998Article
- Regulation of cell motility by mitogen-activated protein kinase.The Journal of cell biology · 1997Article
- Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
A novel, 208-kDa myosin light chain kinase (MLCK) distinct from smooth muscle and non-muscle MLCK has been identified by cross-reaction to two antibodies raised against smooth muscle MLCK. Additional antibodies directed against the amino and carboxyl termini of the smooth muscle MLCK do not react with the 208-kDa MLCK, suggesting these regions are distinct. 208-kDa MLCK phosphorylates 20-kDa myosin light chains in a Ca2+/calmodulin-dependent manner, consistent with it being a member of the MLCK family. Expression of 208-kDa MLCK and smooth muscle MLCK appears to be inversely regulated, with 208-kDa MLCK being most abundant during early development and declining at birth. In contrast, expression of smooth muscle MLCK is relatively low early during development and increases to become the predominant MLCK detected in all adult smooth and non-muscle tissues. The developmental expression pattern of the 208-kDa MLCK suggests this form be named, embryonic MLCK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.