ArticleJapanese journal of cancer research : Gann1995
Restoration of the cellular senescence program and repression of telomerase by human chromosome 3.
Article in Japanese journal of cancer research : Gann, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 126 citations in OpenAlex.
- Modeling specific aneuploidies: from karyotype manipulations to biological insights.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Epigenetic and genetic inactivation of tumor suppressor miR-135a in non-small-cell lung cancer.Thoracic cancer · 2023Article
- Review
- Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.PloS one · 2012Article
- Identification of PITX1 as a TERT suppressor gene located on human chromosome 5.Molecular and cellular biology · 2011Article
- Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering.Genome integrity · 2010Article
- Article
- Significance of cellular senescence in aging and cancer.Cancer research and treatment · 2009Article
- The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.Chromosoma · 2005Review
- Functional identification of a BAC clone from 16q24 carrying a senescence gene SEN16 for breast cancer cells.Oncogene · 2005Article
- Relationship between 3p deletions and telomerase activity in non-small-cell lung cancer: prognostic implications.British journal of cancer · 2004Article
- Identification of a </= 600-kb region on human chromosome 1q42.3 inducing cellular senescence.Oncogene · 2003Article
- Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.Oncogene · 2002Review
- Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis.Oncogene · 2002Review
- Review
- hTR repressor-related gene on human chromosome 10p15.1.British journal of cancer · 2001Article
- Article
- Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Establishment of novel human esophageal cancer cell line in relation to telomere dynamics and telomerase activity.Digestive diseases and sciences · 2000Article
- Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. Deletion of a gene(s) on chromosome 3 is common in human renal cell carcinoma (RCC) and reintroduction of a normal chromosome 3 into an RCC immortal cell line restored the program of cellular senescence. The loss of indefinite growth potential was associated with the loss of telomerase activity and shortening of telomeres in the RCC cells with a normal chromosome 3. However, microcell hybrids that escaped from senescence and microcell hybrids with an introduced chromosome 7 or 11 maintained telomere lengths and telomerase activity similar to those of the parental RCC23. Thus, restoration of the cellular senescence program by chromosome 3 is associated with repression of telomerase function in RCC cells.
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