ReviewClinical rheumatology1995
Ro/SS-A and La/SS-B: autoantigens in Sjögren's syndrome?
Review in Clinical rheumatology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 12 citations in OpenAlex.
- Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection.Transplantation direct · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sjögren's syndrome is characterized serologically by the presence of autoantibodies against Ro/SS-A and La/SS-B. The mechanisms by which these autoantibodies arise is not clear at this moment. B cells capable of producing antibodies to Ro/SS-A and La/SS-B seem to be present in every individual; whether or not an individual indeed makes these antibodies is governed by T cells. Recent experiments from us and from others indicate that T cell tolerance towards Ro/SS-A and La/SS-B can be broken by immunization of normal mice with recombinant human Ro/SS-A or La/SS-B. The specificity of the T cells directing the anti-Ro/SS-A and anti-La/SS-B autoantibody response in these animals has not yet been elucidated. T cells may either be directed against foreign epitopes present on the human immunogen or they may be truly autoreactive. In patients with Sjögren's syndrome, a comparable immunization route might encompass product of viral origin directing the T cell response via RNA/protein complexes. Putative candidates comprise viruses that make use of RNAse polymerase-III, such as Epstein Barr virus, adenovirus, vesicular stomatitis virus en rabies virus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.