ArticleAnnals of the rheumatic diseases1995
Interleukin-1 expression by neutrophils in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Anti-type II collagen immune complex-induced granulocyte reactivity is associated with joint erosions in RA patients with anti-collagen antibodies.Arthritis research & therapy · 2015Article
- Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation.Journal of leukocyte biology · 2012Review
- SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.The Journal of clinical investigation · 2006Article
- The use of anakinra in juvenile arthritis.Current rheumatology reports · 2005Review
- A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation.The American journal of pathology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if neutrophils from blood and synovial fluid of patients with rheumatoid arthritis and other joint arthropathies express interleukin-1 beta mRNA.
methodsRNA was isolated from neutrophils from patient and control blood, and synovial fluid of patients, probed in northern blots, and quantified by densitometry. It was also isolated and analysed from control blood neutrophils after incubation in vitro with granulocyte macrophage colony stimulating factor (GM-CSF).
resultsNeutrophils from the synovial fluid of patients with rheumatoid arthritis contained low levels of mRNA for interleukin-1 beta--between 0.1 and 2% of those observed during stimulation of control neutrophils with GM-CSF for one hour. Higher levels (4-40% of the maximal GM-CSF values) were observed in blood neutrophils from patients with rheumatoid arthritis.
conclusionsNeutrophils contribute to the cytokine network in rheumatoid arthritis. In some circumstances, activation of transcription may occur within the circulation of these patients.
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