ArticleAnnals of the rheumatic diseases1995
Differential distribution of annexins-I, -II, -IV, and -VI in synovium.
Article in Annals of the rheumatic diseases, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.Cell death & disease · 2021Article
- Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis.Stem cells international · 2021Article
- The N-Formyl Peptide Receptors and Rheumatoid Arthritis: A Dangerous Liaison or Confusing Relationship?Frontiers in immunology · 2021Review
- Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.Science translational medicine · 2015Article
- A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis.British journal of pharmacology · 2014Article
- Analysis of lymphocytes in patients with Plasmodium vivax malaria and its relation to the annexin-A1 and IL-10.Malaria journal · 2013Article
- Annexin A1: potential for glucocorticoid sparing in RA.Nature reviews. Rheumatology · 2013Review
- The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.Annals of the rheumatic diseases · 2012Article
- Cell-based meniscal tissue engineering: a case for synoviocytes.Clinical orthopaedics and related research · 2011Review
- Macrophages in synovial inflammation.Frontiers in immunology · 2011Article
- Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics.British journal of pharmacology · 2009Review
- Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.British journal of pharmacology · 2008Review
- Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome.Journal of clinical immunology · 2008Article
- Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1.Mediators of inflammation · 2006Article
- Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky.Arthritis research & therapy · 2004Review
- Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model.Journal of immunology (Baltimore, Md. : 1950) · 2002Article
- Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes.Mediators of inflammation · 2000Article
- Inflammatory neutrophils secrete annexin 1 during experimentally induced colitis in rats.Digestive diseases and sciences · 1999Article
- Glucocorticoid inhibition of adjuvant arthritis synovial macrophage nitric oxide production: role of lipocortin 1.Clinical and experimental immunology · 1998Article
- Antiinflammatory effect of lipocortin 1 in experimental arthritis.Inflammation · 1997Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the distribution of four annexins in non-inflamed rheumatoid arthritic and osteoarthritic synovial tissue.
methodsFrozen sections were stained with monoclonal antibodies (MAb) specific for annexins-I, -II, -IV, and -VI, and for cell lineage related markers including CD68 and CD14 (macrophages), prolyl hydroxylase (fibroblasts), and CD3 (T cells).
resultsEach of the annexins was present in synovial tissues in significant amounts in the three groups studied. Annexin-I was predominantly found within the synovial lining layer and double labelling showed it to be present predominantly in cells of the macrophage lineage. In rheumatoid specimens there was increased staining within the lining layer, perivascularly and on macrophages within the tissue stroma. Annexin-II was present in a distribution similar to that of annexin-I, but with more prominent perivascular staining. Annexins-IV and -VI were seen chiefly in association with areas of lymphocyte infiltration in rheumatoid tissue, whereas annexins-I and -II were absent from these areas. Endothelial cells stained weakly positive for annexins-I and -II, and more strongly for -IV and -VI.
conclusionsThis study demonstrates that annexins (particularly annexin-I, a putative mediator of the anti-inflammatory activities of glucocorticoids) are abundant in rheumatoid and non-rheumatoid synovial tissue, annexins-IV and -VI having a distribution distinct from that of -I and -II.
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