ArticleArchives of disease in childhood1995
Persistent increase in plasma and urinary leukotrienes after acute asthma.
Article in Archives of disease in childhood, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children.The Cochrane database of systematic reviews · 2012Pooled it
- Canadian Asthma Consensus Report, 1999. Canadian Asthma Consensus Group.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1999Guideline
- Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) in patients with allergic rhinitis.Molecular biology reports · 2020Trial
- Neutrophil swarming: Is a good offense the best defense?iScience · 2023Review
- LTA4H rs2660845 association with montelukast response in early and late-onset asthma.PloS one · 2021Article
- Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma.American journal of respiratory cell and molecular biology · 2019Article
- Importance of the leukotriene B4-BLT1 and LTB4-BLT2 pathways in asthma.Seminars in immunology · 2017Review
- Plasma LTE4/PGF2α Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation.Allergy, asthma & immunology research · 2017Article
- Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma.Tuberculosis and respiratory diseases · 2017Review
- Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma.Frontiers in medicine · 2017Article
- P2Y12 antagonist attenuates eosinophilic inflammation and airway hyperresponsiveness in a mouse model of asthma.Journal of cellular and molecular medicine · 2016Article
- Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2014Article
- Lipid mediators and allergic diseases.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Review
- Sputum inflammatory profile before and after specific inhalation challenge in individuals with suspected occupational asthma.PloS one · 2013Article
- Role of Leukotrienes and Leukotriene Modifiers in Asthma.Pharmaceuticals (Basel, Switzerland) · 2010Review
- The role of antileukotriene drugs in management of rhinitis and rhinosinusitis.Current allergy and asthma reports · 2007Review
- Treating asthma in the older patient: is there a place for leukotriene modifiers?Drugs & aging · 2006Review
- Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation.Thorax · 2004Article
- Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma.Archives of disease in childhood · 2000Article
- Bronchial asthma: recent advances.Indian journal of pediatrics · 2000Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukotrienes may mediate bronchoconstriction in asthma. Cysteinyl leukotriene production rises in vivo after allergen challenge, but few reports describe leukotriene concentrations in clinical asthma or in children. Using high performance liquid chromatography/radioimmunoassay, plasma and urinary leukotrienes in asthmatic children (aged 5-10 years) were measured during an acute exacerbation (peak expiratory flow (PEF) < 65%, n = 10) and one month later (PEF 74-169%, n = 9), and in non-atopic normal children (aged 1.3-13.2 years). In the asthmatics, geometric mean (95% confidence interval) plasma leukotriene B4 (LTB4) was 746 pg/ml (398 to 1403) acutely and 1026 pg/ml (662 to 1593) in remission, compared with 369 pg/ml (167 to 728) in the normal children (n = 14). Plasma cysteinyl leukotrienes were low or undetectable, but urinary leukotriene E4 (LTE4) was higher in the asthmatics during an acute episode (210 pmol/mmol creatinine, 101 to 454) and at follow up (179 pmol/mmol, 110 to 293), compared with the normal children (98 pmol/mmol, 81 to 118, n = 41). This persistent increase in plasma LTB4 and urinary LTE4 concentrations one month after a severe asthmatic episode suggests leukotriene production is related to chronic inflammation rather than to acute bronchoconstriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.