Evidence map›Paper›PMID 7492115›Full record

ArticleAntimicrobial agents and chemotherapy1995

Efficacy of the herbicide trifluralin against four P-glycoprotein-expressing strains of Leishmania.

M M Chan, M Grogl, H Callahan, D Fong

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M M ChanDepartment of Biological Sciences, Rutgers, State University of New Jersey, Piscataway 08855-1059, USA.
M Grogl
H Callahan
D Fong

Funding

NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESISR01AI045555 · NIAID · TEMPLE UNIVERSITY · PI CHAN, MARION MAN-YING · 2000 to 2004
$923k
Counterblance in InflammationR21AR051761 · NIAMS · TEMPLE UNIVERSITY · PI CHAN, MARION MAN-YING · 2004 to 2005
$151k
NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESISR21AI045555 · NIAID · TEMPLE UNIVERSITY · PI CHAN, MARION MAN-YING · 2000 to 2000
$50k
NIAID NIH HHS R01 AI045555NIAID NIH HHS R21 AI045555NIAMS NIH HHS R21 AR051761
6 · The paper itself

Abstract

Drug resistance has emerged as a major obstacle to chemotherapy for many infectious diseases. Trifluralin, an antimicrotubule herbicide, is a new experimental drug for treatment of leishmaniasis. Here, we found that it was effective against two strains of Leishmania that express the multidrug-resistant genes ldmdr1 and lmpgpA and two strains that express proteins that are immunologically cross-reactive with mammalian P glycoproteins. These results suggest that trifluralin is not subject to counteractions of these multidrug resistance mechanisms of Leishmania species.

Indexed as

AnimalsATP Binding Cassette Transporter, Subfamily B, Member 1Bacterial ProteinsDrug Resistance, MultipleLeishmania donovaniLeishmania majorMicrobial Sensitivity TestsTransfectionTrifluralinATP Binding Cassette Transporter, Subfamily B, Member 1Bacterial ProteinsTrifluralin

Identifiers

PMID7492115
PMCPMC162792

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.