ArticleMutation research1995
The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols.
Article in Mutation research, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II.The Journal of biological chemistry · 2001Article
- Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities.American journal of human genetics · 1999Review
- The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast.Molecular and cellular biology · 1999Article
- Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes.Molecular and cellular biology · 1997Article
- Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
- Retraction · 2006-12-09Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Investigation by Third Party · Misconduct by Author · Unreliable Data · Unreliable Results and/or Conclusions · · Steven Anthony Leadon named for misconduct. See also: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259672/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019656/
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transcription-coupled repair of H2O2-induced thymine glycols and UV-induced pyrimidine dimers has been shown to occur in the yeast Saccharomyces cerevisiae. In order to determine whether the preferential repair of thymine glycols is carried out by the same nucleotide excision repair complex that removes pyrimidine dimers, we examined the repair of thymine glycols in two yeast mutants, rad1 delta and rad2 delta, in which the nucleotide excision repair pathway was disrupted. We find that in both wild-type and a rad1 delta mutant, repair of thymine glycols occurs faster on the transcribed strand of the GAL7 gene than on the nontranscribed strand. This indicates that transcription-coupled repair can occur in the absence of nucleotide excision repair and that repair of oxidative DNA damage initiated by an N-glycosylase can be coupled to transcription. In contrast, the initial rate of repair of thymine glycols on the transcribed strand of the GAL7 gene in a rad2 delta mutant is significantly slower than that for the wild-type cells, with kinetics similar to that of the nontranscribed strand. However, by 60 min post-treatment, the amount of repair on the transcribed strand in the rad2 delta eventually reaches that of the wild-type cells. We conclude that repair of oxidative DNA damage, such as thymine glycols, can be coupled to transcription and that RAD2 facilitates transcription-coupled repair of oxidative DNA damage in yeast.
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