ArticleThe Journal of cell biology1995
Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 108 citations in OpenAlex.
- Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.The Journal of cell biology · 2022Article
- Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae.PloS one · 2022Article
- Exploratory polarization facilitates mating partner selection inMolecular biology of the cell · 2021Article
- Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway.The Journal of biological chemistry · 2019Article
- Quantitative analysis of the yeast pheromone pathway.Yeast (Chichester, England) · 2019Article
- Yeast chemotropism: A paradigm shift in chemical gradient sensing.Cellular logistics · 2017Article
- Gamete signalling underlies the evolution of mating types and their number.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Modelling of Yeast Mating Reveals Robustness Strategies for Cell-Cell Interactions.PLoS computational biology · 2016Article
- Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating.Current biology : CB · 2016Article
- Cell biology of yeast zygotes, from genesis to budding.Biochimica et biophysica acta · 2015Review
- Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore.Molecular biology reports · 2014Article
- Pheromone-induced morphogenesis improves osmoadaptation capacity by activating the HOG MAPK pathway.Science signaling · 2013Article
- Mate and fuse: how yeast cells do it.Open biology · 2013Review
- Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Microbiology and molecular biology reviews : MMBR · 2012Review
- Yeast dynamically modify their environment to achieve better mating efficiency.Science signaling · 2011Article
- Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase.The Journal of biological chemistry · 2011Article
- Polarization of the yeast pheromone receptor requires its internalization but not actin-dependent secretion.Molecular biology of the cell · 2010Article
- Chemical gradients and chemotropism in yeast.Cold Spring Harbor perspectives in biology · 2009Review
- Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.Current biology : CB · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During conjugation, haploid S. cerevisiae cells find one another by polarizing their growth toward each other along gradients of pheromone (chemotropism). We demonstrate that yeast cells exhibit a second mating behavior: when their receptors are saturated with pheromone, wild-type a cells execute a default pathway and select a mate at random. These matings are less efficient than chemotropic matings, are induced by the same dose of pheromone that induces shmoo formation, and appear to use a site near the incipient bud site for polarization. We show that the SPA2 gene is specifically required for the default pathway: spa2 delta mutants cannot mate if pheromone concentrations are high and gradients are absent, but can mate if gradients are present. ste2 delta, sst2 delta, and far1 delta mutants are chemotropism-defective and therefore must choose a mate by using a default pathway; consistent with this deduction, these strains require SPA2 to mate. In addition, our results suggest that far1 mutants are chemotropism-defective because their mating polarity is fixed at the incipient bud site, suggesting that the FAR1 gene is required for inhibiting the use of the incipient bud site during chemotropic mating. These observations reveal a molecular relationship between the mating and budding polarity pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.