ArticleThe Journal of cell biology1995
Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 240 citations in OpenAlex.
- Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Trial
- Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis.Nature aging · 2026Article
- Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.Reproductive toxicology (Elmsford, N.Y.) · 2022Review
- Liver Receptor homolog-1 Regulates Apoptosis of Bovine Ovarian Granulosa Cells by Progestogen Receptor Signaling Pathway.Animals : an open access journal from MDPI · 2022Article
- Impact of cholesterol-pathways on breast cancer development, a metabolic landscape.Journal of Cancer · 2021Review
- Morphological, hormonal, and molecular changes in different maternal tissues during lactation and post-lactation.The journal of physiological sciences : JPS · 2019Review
- Oxybenzone Alters Mammary Gland Morphology in Mice Exposed During Pregnancy and Lactation.Journal of the Endocrine Society · 2018Article
- Bisphenol S Alters the Lactating Mammary Gland and Nursing Behaviors in Mice Exposed During Pregnancy and Lactation.Endocrinology · 2017Article
- Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates.International journal of experimental pathology · 2017Article
- The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.Endocrine-related cancer · 2017Review
- Differential relationships between chronic hormone profiles in pregnancy and maternal investment in rhesus monkey mothers with hair loss in the neonatal period.American journal of primatology · 2017Article
- Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors.Cancer biology & therapy · 2016Article
- Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments.Oncoscience · 2016Review
- The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.Cell death and differentiation · 2016Article
- Serotoninergic and Circadian Systems: Driving Mammary Gland Development and Function.Frontiers in physiology · 2016Article
- Expression microarray identifies the unliganded glucocorticoid receptor as a regulator of gene expression in mammary epithelial cells.BMC cancer · 2014Article
- A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary.Endocrinology · 2013Review
- Ductal barriers in mammary epithelium.Tissue barriers · 2013Review
- Milk yield responses to changes in milking frequency during early lactation are associated with coordinated and persistent changes in mammary gene expression.BMC genomics · 2013Article
- Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Milk production during lactation is a consequence of the suckling stimulus and the presence of glucocorticoids, prolactin, and insulin. After weaning the glucocorticoid hormone level drops, secretory mammary epithelial cells die by programmed cell death and the gland is prepared for a new pregnancy. We studied the role of steroid hormones and prolactin on the mammary gland structure, milk protein synthesis, and on programmed cell death. Slow-release plastic pellets containing individual hormones were implanted into a single mammary gland at lactation. At the same time the pups were removed and the consequences of the release of hormones were investigated histologically and biochemically. We found a local inhibition of involution in the vicinity of deoxycorticosterone- and progesterone-release pellets while prolactin-release pellets were ineffective. Dexamethasone, a very stable and potent glucocorticoid hormone analogue, inhibited involution and programmed cell death in all the mammary glands. It led to an accumulation of milk in the glands and was accompanied by an induction of protein kinase A, AP-1 DNA binding activity and elevated c-fos, junB, and junD mRNA levels. Several potential target genes of AP-1 such as stromelysin-1, c-jun, and SGP-2 that are induced during normal involution were strongly inhibited in dexamethasone-treated animals. Our results suggest that the cross-talk between steroid hormone receptors and AP-1 previously described in cells in culture leads to an impairment of AP-1 activity and to an inhibition of involution in the mammary gland implying that programmed cell death in the postlactational mammary gland depends on functional AP-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.