ArticleImmunology1995
Induced expression of mRNA for IL-5, IL-6, TNF-alpha, MIP-2 and IFN-gamma in immunologically activated rat peritoneal mast cells: inhibition by dexamethasone and cyclosporin A.
Article in Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 96 citations in OpenAlex.
- Hurdles to Cardioprotection in the Critically Ill.International journal of molecular sciences · 2019Review
- Mast cells as sources of cytokines, chemokines, and growth factors.Immunological reviews · 2018Review
- S-allyl-cysteine attenuates carbon tetrachloride-induced liver fibrosis in rats by targeting STAT3/SMAD3 pathway.American journal of translational research · 2018Article
- Astragaloside IV ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin D3-upregulated protein 1/NF-κB signaling pathway.Experimental and therapeutic medicine · 2016Article
- Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS.The Journal of biological chemistry · 2016Article
- Mast cell function: a new vision of an old cell.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Review
- Left ventricular remodeling with preserved function after coronary microembolization: the effect of methylprednisolone.European journal of medical research · 2014Article
- One dose of cyclosporine A is protective at initiation of folic acid-induced acute kidney injury in mice.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2008Review
- Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580.Clinical and experimental immunology · 2004Article
- Article
- Activation of macrophage nuclear factor-kappa B and induction of inducible nitric oxide synthase by LPS.Respiratory research · 2002Article
- Activation of nuclear factor kappaB and induction of inducible nitric oxide synthase by Ureaplasma urealyticum in macrophages.Infection and immunity · 2000Article
- Protective role for interleukin-5 during chronic Toxoplasma gondii infection.Infection and immunity · 1999Article
- Eotaxin and eotaxin receptor (CCR3) expression in Sephadex particle-induced rat lung inflammation.International journal of experimental pathology · 1999Article
- Mast cell activation and migration to lymph nodes during induction of an immune response in mice.The Journal of clinical investigation · 1998Article
- A role for mast cells in the development of adjuvant-induced vasculitis and arthritis.The American journal of pathology · 1998Article
- Induction of interleukin-4 and interleukin-5 expression in mast cells is inhibited by glucocorticoids.Clinical and diagnostic laboratory immunology · 1998Article
- The strain difference in the effect of mercuric chloride on antigen-triggered serotonin release from rat mast cells is not mediated via interferon-gamma.Immunology · 1996Article
- Observations of Forsythia koreana methanol extract on mast cell-mediated allergic reactions in experimental models.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the capacity of purified rat peritoneal connective tissue-type mast cells (PMC) to express mRNA for several cytokines. Stimulation of PMC with anti-IgE for 4 hr induced the expression of mRNA encoding interleukin-5 (IL-5), IL-6, tumour necrosis factor-alpha (TNF-alpha), macrophage inflammatory protein-2 (MIP-2) and interferon-gamma (IFN-gamma). Unstimulated PMC expressed detectable mRNA for TNF-alpha but not for the other four cytokines. Incubation of PMC with cyclosporin A (CsA) or dexamethasone (DEX), each at 10(-6) M for 24 hr, significantly inhibited the induced expression of mRNA for each of the five cytokines, and also inhibited release of biologically active TNF-alpha. Throughout these experiments mRNA levels of the housekeeping gene G3PDH were not altered by stimulation with anti-IgE or incubation with CsA or DEX. We conclude that immunological activation of rat PMC induces gene expression of several cytokines and that expression of these genes can be inhibited by immunosuppressive drugs.
Indexed as
Identifiers
7490125PMC1384002W2414674520What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.