ArticleThe EMBO journal1995
dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.The Journal of biological chemistry · 2015Article
- Dynamics of endoreplication during Drosophila posterior scutellar macrochaete development.PloS one · 2012Article
- Genome-wide comprehensive analysis of human helicases.Communicative & integrative biology · 2011Article
- Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.Journal of cell science · 2010Article
- Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles.Genetics · 2010Article
- Identification and expression analysis of minichromosome maintenance proteins in the silkworm, Bombyx mori.Journal of insect science (Online) · 2010Article
- The origin recognition complex is dispensable for endoreplication in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells.PloS one · 2007Article
- A genetic analysis of the Drosophila mcm5 gene defines a domain specifically required for meiotic recombination.Genetics · 2007Article
- Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- REC, Drosophila MCM8, drives formation of meiotic crossovers.PLoS genetics · 2005Article
- SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex.Genetics · 2004Article
- Eukaryotic MCM proteins: beyond replication initiation.Microbiology and molecular biology reviews : MMBR · 2004Review
- Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae.Current biology : CB · 2004Article
- Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication.Molecular biology of the cell · 2002Article
- Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.Genes & development · 2000Article
- Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element.Genes & development · 1999Article
- Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster.Molecular and cellular biology · 1999Article
- Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles.The Journal of cell biology · 1998Article
- Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We have isolated the Drosophila disc proliferation abnormal (dpa) gene, a member of the MCM family of DNA replication factors. Members of this family of proteins are required for DNA replication in yeast. A dpa null mutant dies during pupal stages because imaginal tissues necessary for the formation of the adult fly fail to proliferate normally. Beginning in late embryogenesis BrdU labeling reveals DNA replication defects in mitotically proliferating cells. In contrast, dpa is dispensable for endoreplication, a specialized cell cycle consisting of consecutive rounds of S phases without intervening mitosis. Our studies suggest an essential role for dpa in mitotic DNA replication but not in endoreplication. Thus, dpa is not a general replication factor but may play a specialized regulatory role in DNA replication.
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