ArticleThe EMBO journal1995
Mutants in a yeast Ran binding protein are defective in nuclear transport.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 146 citations in OpenAlex.
- Ran modulates allosteric crosstalk between importin β surfaces.Nature communications · 2025Article
- Dissecting the roles of Cse1 and Nup2 in classical NLS-cargo release in vivo.Traffic (Copenhagen, Denmark) · 2020Article
- Study of Humoral Responses againstVaccines · 2019Article
- Identification of Genes inG3 (Bethesda, Md.) · 2017Article
- Article
- Sumoylation regulates Kap114-mediated nuclear transport.The EMBO journal · 2012Article
- Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import.The Journal of biological chemistry · 2009Article
- Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation.The Journal of biological chemistry · 2009Review
- Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.Molecular and cellular biology · 2009Article
- Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Current genetics · 2008Article
- Nuclear import of zinc binuclear cluster proteins proceeds through multiple, overlapping transport pathways.Eukaryotic cell · 2003Article
- Amino acid-dependent Gcn4p stability regulation occurs exclusively in the yeast nucleus.Eukaryotic cell · 2002Article
- The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import.The Journal of cell biology · 2002Article
- Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast.Molecular and cellular biology · 2002Article
- The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).Molecular biology of the cell · 2001Article
- Article
- Factors affecting nuclear export of the 60S ribosomal subunit in vivo.Molecular biology of the cell · 2000Article
- Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.Molecular and cellular biology · 2000Article
- Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway.Molecular and cellular biology · 2000Article
- Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ran, a Ras-like GTPase, has been implicated in controlling the movement of proteins and RNAs in and out of the nucleus. We have constructed strains of Saccharomyces cerevisiae which produce fusion proteins containing glutathione-S-transferase (GST) fused to Gsp1p, which encodes the essential yeast Ran homolog, and a mutant form of Gsp1p that mimics the GTP-bound state. A major protein with the apparent size of 34 kDa co-purifies with the GTP-bound form of Gsp1p. This protein was identified as Yrb1p (Yeast Ran Binding Protein) and stimulates GTP hydrolysis by Gsp1p in the presence of Rna1p, the Gsp1 GTPase activating protein. Yrb1p is located in the cytoplasm with some concentration at the nuclear periphery. Temperature-sensitive yrb1 mutants are defective in nuclear protein import and RNA export. A mutation in the highly conserved Ran binding region of Yrb1p reduces its ability to interact with Gsp1p. These data indicate that Yrb1p functions with Gsp1p and suggest that together they can control transport of macromolecules across the nuclear envelope.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.