ArticleThe EMBO journal1995
Rac GTPase interacts with GAPs and target proteins through multiple effector sites.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 126 citations in OpenAlex.
- Unravelling molecular dynamics in living cells: Fluorescent protein biosensors for cell biology.Journal of microscopy · 2025Review
- Asciminib in the treatment of chronic myeloid leukemia in chronic phase.Future oncology (London, England) · 2025Review
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Regulation of NADPH Oxidase-Mediated Superoxide Production by Acetylation and Deacetylation.Frontiers in physiology · 2021Article
- The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism.Antioxidants & redox signaling · 2019Review
- Bioinformatics analysis of microarray data to reveal the pathogenesis of brain ischemia.Molecular medicine reports · 2018Article
- Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.PloS one · 2017Article
- Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.Journal of the National Cancer Institute · 2016Article
- Toward understanding RhoGTPase specificity: structure, function and local activation.Small GTPases · 2014Review
- Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.Small GTPases · 2014Review
- Article
- Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.Biochimica et biophysica acta · 2012Article
- Coordination of Rho and Rac GTPase function via p190B RhoGAP.Current biology : CB · 2008Article
- Article
- Assembly of the phagocyte NADPH oxidase.Histochemistry and cell biology · 2004Review
- The small GTPase Rac is involved in clustering of hippocampal neurons and fasciculation of their neurites.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.Current biology : CB · 2003Article
- Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells.Molecular and cellular biology · 2002Article
- Determination of interaction sites of phospholipase D1 for RhoA.The Biochemical journal · 2001Article
- Isolation and characterization of effector-loop mutants of CDC42 in yeast.Molecular biology of the cell · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rac, a small GTPase in the ras superfamily, regulates at least two biological processes in animal cells: (i) the polymerization of actin and the assembly of integrin complexes to produce lamellipodia and ruffles; and (ii) the activity of an NADPH oxidase in phagocytic cells. NADPH oxidase activation is mediated through a rac effector protein, p67phox, and using chimeras made between rac and the closely related GTPase, rho, we have identified two distinct effector sites in rac, one N-terminal and one C-terminal, both of which are required for activation of p67phox. The same two effector sites are essential for rac-induced actin polymerization in fibroblasts. p65PAK, a ubiquitous serine/threonine kinase, interacts with rac at both the N- and C-terminal effector sites, but the GTPase-activating protein, bcr interacts with rac at a different region. This makes p65PAK, but not bcr, a candidate effector of rac-induced lamellipodium formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.