ArticleThe EMBO journal1995
Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 87 citations in OpenAlex.
- Modulation of Adipose-Derived Mesenchymal Stem/Stromal Cell Transcriptome by G-CSF Stimulation.Stem cells international · 2020Article
- Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.The Journal of biological chemistry · 2015Article
- miR-155 is associated with the leukemogenic potential of the class IV granulocyte colony-stimulating factor receptor in CD34⁺ progenitor cells.Molecular medicine (Cambridge, Mass.) · 2015Article
- Selective expansion of transduced cells for hematopoietic stem cell gene therapy.International journal of hematology · 2002Review
- In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model.Gene therapy · 2002Article
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- Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy.Gene therapy · 1999Article
- Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Myeloid-specific transcriptional activation by murine myeloid zinc-finger protein 2.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway.Molecular and cellular biology · 1997Article
- Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation.The EMBO journal · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The receptor for granulocyte colony-stimulating factor (G-CSFR) is a hemopoietic growth factor receptor, which mediates proliferation and differentiation signals. The cytoplasmic region of G-CSFR carries four tyrosine residues in its C-terminal half. We constructed mutant receptors in which each tyrosine residue of G-CSFR was mutated to phenylalanine. Two mutant receptors (Tyr703 and Tyr728) neither transduced the growth-inhibitory signal nor induced the neutrophil-specific myeloperoxidase (MPO) gene. The Tyr703 mutant did not induce morphological changes in cells, whereas transformants expressing the Tyr728 mutant adhered to plates with a macrophage-like morphology upon G-CSF stimulation. Mutation of the most distal tyrosine residue (Tyr763) abolished the ability of G-CSFR to stimulate the tyrosine phosphorylation of a cellular protein with an M(r) of 54 kDa. These results indicated that the regions around the three tyrosine residues of G-CSFR play essential and distinct roles in signal transduction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.