ArticleOccupational and environmental medicine1995
Mortality and cancer incidence among secondary lead smelter workers.
Article in Occupational and environmental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Occupational Lead Exposure and Brain Tumors: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- The Comparison of the Plasma Levels of the Lead Element in Patients with Gastrointestinal Cancers and Healthy Individuals.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells.Journal of applied toxicology : JAT · 2015Article
- Susceptibility to particle health effects, miRNA and exosomes: rationale and study protocol of the SPHERE study.BMC public health · 2014Article
- Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
- Association of blood lead concentrations with mortality in older women: a prospective cohort study.Environmental health : a global access science source · 2009Article
- Comprehensive evaluation of long-term trends in occupational exposure: Part 1. Description of the database.Occupational and environmental medicine · 1998Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the mortality pattern and the cancer incidence in a cohort of long term smelter workers exposed to lead.
methodsThe cohort consists of 664 male lead battery workers, employed for at least three months in 1942-87. From 1969 the values of all blood lead samples repeatedly obtained from these workers every two to three months, have been collected in a database. The expected mortality and morbidity 1969-89 was estimated from the county rates, specified for cause, sex, five-year age groups, and calendar year. Individual exposure matrices have been calculated and used for dose-response analyses.
resultsThe total cohort showed an increased overall mortality (standardised mortality ratio (SMR) 1.44; 95% confidence interval (95% CI) 1.16-1.79), an increased mortality from ischaemic heart diseases (SMR 1.72; 95% CI 1.20-2.42) and all malignant neoplasms (SMR 1.65; 95% CI 1.09-2.44). These risk estimates were unaffected or slightly decreased when applying a latency period of 15 years, and no dose-response pattern was shown. The non-significantly raised cancer incidence in the gastrointestinal tract (11 malignancies) in the total cohort, increased to a barely significant level in the quartile with the highest cumulative lead exposure (standardised incidence ratio (SIR) 2.34, 95% CI 1.07-4.45). No clear dose response pattern was evident when further subdividing the data into those first employed up to 1969 v those first employed after 1969 when the blood lead monitoring programme started. The risk estimate for malignancies in the gastrointestinal tract was not related to latency time. The cancer incidence was not increased at other sites.
conclusionsA slightly increased incidence of gastrointestinal cancers was found in workers exposed to lead and employed before 1970. The lead cohort also showed an increased mortality from ischaemic heart diseases. These risk estimates did not show a dose-response pattern and were not associated with latency time. The results must also be interpreted with caution because of limited numbers, and lack of dietary and smoking data.
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