ReviewGene expression1995
Signal transduction and activation of gene transcription by interferons.
Review in Gene expression, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Decoding cell-cell communication in spatial transcriptomics: mechanistic insights, modeling constraints, and analytical caveats.Briefings in bioinformatics · 2026Review
- Incorporating Sequence-Dependent DNA Shape and Dynamics into Transcriptome Data Analysis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Review
- Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.Scientific reports · 2018Article
- The role of HCV proteins on treatment outcomes.Virology journal · 2015Review
- Article
- Replicative homeostasis III: implications for antiviral therapy and mechanisms of response and non-response.Virology journal · 2007Article
- Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha.The EMBO journal · 2002Article
- Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.Journal of virology · 2001Article
- Elimination of duck hepatitis B virus RNA-containing capsids in duck interferon-alpha-treated hepatocytes.Journal of virology · 1999Article
- Engagement of the cellular receptor for glycoprotein B of human cytomegalovirus activates the interferon-responsive pathway.Molecular and cellular biology · 1999Article
- Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.Microbiology and molecular biology reviews : MMBR · 1998Review
- Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.Molecular and cellular biology · 1998Article
- Inhibition of lung colonisation of a mouse mammary carcinoma by therapeutic vaccination with interferon-alpha gene-transduced tumor cells.Clinical & experimental metastasis · 1998Article
- Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.The EMBO journal · 1997Article
- STAT dynamics.Cytokine & growth factor reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Advances in the field of interferon research have identified a signal transduction pathway that initiates at a cell surface receptor and culminates at target genes in the nucleus. The binding of interferon to a transmembrane receptor stimulates the concomitant activation of tyrosine kinases of the Janus kinase (JAK) family. Subsequently, latent cytoplasmic transcription factors are activated by tyrosine phosphorylation and function as signal transducers and activators of transcription (STATs). The STATs form homomeric or heteromeric protein complexes that translocate to the nucleus to bind to specific DNA sequences in the promoters of stimulated genes. The discovery of this regulated pathway in the interferon system served as a paradigm for receptor to nucleus signal transmission by a variety of cytokines.
Indexed as
Identifiers
7488857PMC6138031W54363110What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.